Evidence map›Paper›PMID 28866430›Full record

ReviewGynecologic oncology2017

The role of MicroRNA molecules and MicroRNA-regulating machinery in the pathogenesis and progression of epithelial ovarian cancer.

Xiyin Wang, Mircea Ivan, Shannon M Hawkins

Abstract readReview
In one paragraph

Review in Gynecologic oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiyin WangDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, United States.
Mircea IvanDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States.
Shannon M HawkinsDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address: shhawkin@iu.edu.

Funding

Role of Hypoxia-Induced miR-210 in Tumor MetabolismR01CA155332 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI IVAN, MIRCEA · 2011 to 2015
$1.7M
Lung Cancer Free Survival Among Aged SmokersR03CA091217 · NCI · FOX CHASE CANCER CENTER · PI BAFFOE-BONNIE, AGNES B · 2001 to 2002
$170k
Deletion of Arid1a and Kras as a Model of Endometriosis-Associated Ovarian CancerR03CA191527 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI HAWKINS, SHANNON MICHELLE · 2016 to 2017
$162k
NCI NIH HHS R01 CA155332NCI NIH HHS R03 CA091217NCI NIH HHS R03 CA191527
6 · The paper itself

Abstract

MicroRNA molecules are small, single-stranded RNA molecules that function to regulate networks of genes. They play important roles in normal female reproductive tract biology, as well as in the pathogenesis and progression of epithelial ovarian cancer. DROSHA, DICER, and Argonaute proteins are components of the microRNA-regulatory machinery and mediate microRNA production and function. This review discusses aberrant expression of microRNA molecules and microRNA-regulating machinery associated with clinical features of epithelial ovarian cancer. Understanding the regulation of microRNA molecule production and function may facilitate the development of novel diagnostic and therapeutic strategies to improve the prognosis of women with epithelial ovarian cancer. Additionally, understanding microRNA molecules and microRNA-regulatory machinery associations with clinical features may influence prevention and early detection efforts.

Indexed as

AnimalsCarcinoma, Ovarian EpithelialDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMicroRNAsNeoplasms, Glandular and EpithelialOvarian NeoplasmsRNA, NeoplasmMicroRNAsRNA, NeoplasmArgonauteDicerDroshaEpithelial ovarian cancerFemale reproductive tract cancerMicroRNA molecules

Identifiers

PMID28866430
PMCPMC5741188

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.