ArticleNeuroImage2017
Individual differences in regional cortical volumes across the life span are associated with regional optical measures of arterial elasticity.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 30 citations in OpenAlex.
- Ultrafast fMRI Detects Age-Related Changes in Harmonics of Cardiac Pulsations in the Brain at 7 T.Magnetic resonance in medicine · 2026Article
- Regional cerebral arterial elasticity is associated with cardiovascular health in cognitively healthy older adults.bioRxiv : the preprint server for biology · 2026Article
- Region-specific associations between cerebral arterial elasticity and grey matter volume: Evidence for lateral prefrontal vulnerability.bioRxiv : the preprint server for biology · 2025Article
- Ultrafast fMRI detects age-related changes in harmonics of cardiac pulsations in the brain at 7 T.bioRxiv : the preprint server for biology · 2025Article
- Effects of Aging, Estimated Fitness, and Cerebrovascular Status on White Matter Microstructural Health.Human brain mapping · 2025Article
- Age group classification based on optical measurement of brain pulsation using machine learning.Scientific reports · 2025Article
- Neurovascular mechanisms of cognitive aging: Sex-related differences in the average progression of arteriosclerosis, white matter atrophy, and cognitive decline.Neurobiology of disease · 2024Article
- Enhancing diffuse correlation spectroscopy pulsatile cerebral blood flow signal with near-infrared spectroscopy photoplethysmography.Neurophotonics · 2023Article
- BOLD cardiorespiratory pulsatility in the brain: from noise to signal of interest.Frontiers in human neuroscience · 2023Review
- The physiological basis underlying functional connectivity differences in older adults: A multi-modal analysis of resting-state fMRI.Brain imaging and behavior · 2022Article
- Characterising activity and diet compositions for dementia prevention: protocol for the ACTIVate prospective longitudinal cohort study.BMJ open · 2022Article
- Cerebrovascular Function, Vascular Risk, and Lifestyle Patterns in Resistant Hypertension.Journal of Alzheimer's disease : JAD · 2022Article
- A healthy mind in a healthy body: Effects of arteriosclerosis and other risk factors on cognitive aging and dementia.The psychology of learning and motivation · 2022Article
- Coronary artery disease and its impact on the pulsatile brain: A functional NIRS study.Human brain mapping · 2021Article
- Aging and cerebrovascular health: Structural, functional, cognitive, and methodological implications.Psychophysiology · 2021Article
- Age-related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review.Psychophysiology · 2021Review
- The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review.Molecules (Basel, Switzerland) · 2021Review
- Longitudinal Impact of Physical Activity on Brain Pulsatility Index and Cognition in Older Adults with Cardiovascular Risk Factors: A NIRS Study.Brain sciences · 2021Article
- Region-specific vulnerability in neurodegeneration: lessons from normal ageing.Ageing research reviews · 2021Review
- Age-related differences in functional brain network segregation are consistent with a cascade of cerebrovascular, structural, and cognitive effects.Network neuroscience (Cambridge, Mass.) · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Aging is often accompanied by changes in brain anatomy and cerebrovascular health. However, the specific relationship between declines in regional cortical volumes and loss of cerebral arterial elasticity is less clear, as only global or very localized estimates of cerebrovascular health have been available. Here we employed a novel tomographic optical method (pulse-DOT) to derive local estimates of cerebral arterial elasticity and compared regional volumetric estimates (obtained with FreeSurfer) with optical arterial elasticity estimates from the same regions in 47 healthy adults (aged 18-75). Between-subject analyses revealed a global correlation between cortical volume and cortical arterial elasticity, which was a significant mediator of the association between age and cortical volume. Crucially, a novel within-subject analysis highlighted the spatial association between regional variability in cortical volumes and arterial elasticity in the same regions. This association strengthened with age. Gains in the predictability of cortical volumes from arterial elasticity data were obtained by sharpening the resolution up to individual cortical regions. These results indicate that some of the variance of sub-clinical age-related brain atrophy is associated with differences in the status of cerebral arteries, and can help explain the unique patterns of brain atrophy found within each individual.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.