ArticleThe journal of allergy and clinical immunology. In practice
Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age.
Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 1 of them a synthesis that pooled it.
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Who cites it
150 citing papers in PubMed, 1 synthesis or guideline pooled it, 272 citations in OpenAlex.
- Blood eosinophil counts in the general population and airways disease: a comprehensive review and meta-analysis.The European respiratory journal · 2022Pooled it
- PrecISE-a biomarker-stratified adaptive trial of 5 interventions in severe asthma: Final protocol and the baseline cohort.The Journal of allergy and clinical immunology · 2026Trial
- Measures of ventilation heterogeneity mapped with hyperpolarized helium-3 MRI demonstrate a T2-high phenotype in asthma.Pediatric pulmonology · 2021Trial
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- Development and initial validation of the Asthma Severity Scoring System (ASSESS).The Journal of allergy and clinical immunology · 2020Trial
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- Race Adjusted for Social and Environmental Disparities Is the Principal Determinant of T2HIGH Inflammation in Children With Severe Asthma.The journal of allergy and clinical immunology. In practice · 2026Article
- Rhinovirus-infected preschool children with problematic wheeze have lung eosinophilic inflammation.The Journal of allergy and clinical immunology · 2026Article
- Adverse outcomes in young adults with severe asthma: results from the UK Severe Asthma Registry.ERJ open research · 2026Article
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- Serum Eosinophil Cationic Protein (ECP) as a Biomarker for Distinguishing Pediatric Allergic Airway Diseases.International journal of molecular sciences · 2026Article
- Phenotyping moderate asthma earlier by analyzing induced sputum eosinophils, blood eosinophils, and atopy: a cross-sectional comparison with severe asthma.Respiratory research & clinical practice · 2026Article
- Sex, hormones, and lung health.Physiological reviews · 2026Review
- A principal component analysis-based endophenotype definition for change in lung function and inhaled corticosteroid treatment response in childhood asthma.Respiratory research · 2025Article
- Mechanisms of superior respiratory IgA responses against SARS-CoV-2 after mucosal vaccination.bioRxiv : the preprint server for biology · 2025Article
- Self-Reported Resilience During the COVID-19 Pandemic.JAMA network open · 2025Article
- Multicohort Analysis of Bronchial Epithelial Cell Expression in Healthy Subjects and Patients with Asthma Reveals Four Clinically Distinct Clusters.American journal of respiratory cell and molecular biology · 2025Article
- Clinical and Biological Features of a Thickened Basement Membrane Zone in Asthma.American journal of respiratory and critical care medicine · 2025Article
- Uncovering Non-Invasive Biomarkers in Paediatric Severe Acute Asthma Using Targeted Exhaled Breath Analysis.Metabolites · 2025Article
- What is the influence of exacerbations on pulmonary function in pediatric and adolescent patients with severe asthma despite controller therapies?Clinical and translational allergy · 2025Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
35 authors at 12 institutions in 1 country.
Funding
Abstract
backgroundThe effect of age on asthma severity is poorly understood.
objectivesThe objective of this study was to compare the baseline features of severe and nonsevere asthma in the Severe Asthma Research Program (SARP) III cohort, and examine in cross section the effects of age on those features.
methodsSARP III is a National Institutes of Health/National Heart Lung Blood Institute multisite 3-year cohort study conducted to investigate mechanisms of severe asthma. The sample included 188 children (111 severe, 77 nonsevere) and 526 adults (313 severe, 213 nonsevere) characterized for demographic features, symptoms, health care utilization, lung function, and inflammatory markers compared by age and severity.
resultsCompared with children with nonsevere asthma, children with severe asthma had more symptoms and more historical exacerbations, but no difference in body weight, post-bronchodilator lung function, or inflammatory markers. After childhood, and increasing with age, the cohort had a higher proportion of women, less allergen sensitization, and overall fewer blood eosinophils. Enrollment of participants with severe asthma was highest in middle-aged adults, who were older, more obese, with greater airflow limitation and higher blood eosinophils, but less allergen sensitization than adults with nonsevere asthma.
conclusionsThe phenotypic features of asthma differ by severity and with advancing age. With advancing age, patients with severe asthma are more obese, have greater airflow limitation, less allergen sensitization, and variable type 2 inflammation. Novel mechanisms besides type 2 inflammatory pathways may inform the severe asthma phenotype with advancing age.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.