Evidence map›Paper›PMID 28866052›Full record

ArticleNeuroscience letters2017

Sleep-inducing effect of substance P-cholera toxin A subunit in mice.

Mark R Zielinski, Dmitry Gerashchenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Roles of Neuropeptides in Sleep-Wake Regulation.International journal of molecular sciences · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mark R ZielinskiVeterans Affairs Boston Healthcare System and Department of Psychiatry, Harvard Medical School, West Roxbury, MA 02132, USA. Electronic address: mark_zielinski@hms.harvard.edu.
Dmitry GerashchenkoVeterans Affairs Boston Healthcare System and Department of Psychiatry, Harvard Medical School, West Roxbury, MA 02132, USA. Electronic address: dmitry_gerashchenko@hms.harvard.edu.
Harvard University · USVA Boston Healthcare System · US

Funding

Role of cortical interneurons in synchronization of brain electroencephalogramR01NS064193 · NINDS · HARVARD MEDICAL SCHOOL · PI GERASHCHENKO, DMITRY · 2010 to 2013
$1.1M
Role of nNOS cortical neurons in slow wave activity production and cognitionR21NS092926 · NINDS · HARVARD MEDICAL SCHOOL · PI GERASHCHENKO, DMITRY · 2015 to 2016
$354k
Sleep Loss and Inflammation in the Neurovascular UnitIK2BX002823 · VA · VA BOSTON HEALTH CARE SYSTEM · PI ZIELINSKI, MARK ROBERT · 2016 to 2020
–
BLRD VA IK2 BX002823NINDS NIH HHS R01 NS064193NINDS NIH HHS R21 NS092926
6 · The paper itself

Abstract

Evidence indicates that the neuropeptide substance P (SP) can act through neurokinin receptors to alter sleep and/or non-rapid eye movement (NREM) sleep slow-wave activity. Consequently, drugs acting on SP receptors could potentially be used as a novel treatment for sleep-related disorders. In the present study, we used SP conjugated with cholera toxin A subunit (SP-CTA), which enhances its duration of activity on SP receptor-expressing cells, to determine the effects of selectively activating SP receptor-expressing brain cells on sleep regulation in mice. Herein, we found that intracerebroventricular administration of SP-CTA enhanced amounts of NREM sleep which was highly fragmented. This result suggests that the activation of SP receptor-expressing cells in the brain can produce not only arousal effects as shown in previous studies but also sleep-inducing effects.

Indexed as

AnimalsCholera ToxinImmunotoxinsInfusions, IntraventricularMaleMiceReceptors, Neurokinin-1SleepSubstance PCholera ToxinImmunotoxinsReceptors, Neurokinin-1Substance PCholera toxin a subunitSleepSleep fragmentationSlow-Wave activitySubstance P

Identifiers

PMID28866052
PMCPMC5624846
OpenAlexW2752872032

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.