Evidence map›Paper›PMID 28865999›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2017

A Novel Vaccine Targeting Glypican-3 as a Treatment for Hepatocellular Carcinoma.

Qunfeng Wu, Liya Pi, Thu Le Trinh, Chaohui Zuo, Man Xia, Yu Jiao, Zhouhua Hou, Sung Jo, William Puszyk, Kien Pham and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Qunfeng WuDepartment of Pathology and Laboratory Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA.
Liya PiDepartment of Pediatrics, University of Florida, Gainesville, FL 32611, USA.
Thu Le TrinhDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA; Department of Immunology, Moffitt Cancer Center, Tampa, FL 33612, USA.
Chaohui ZuoDepartment of Pathology and Laboratory Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA; Department of Gastroduodenal and Pancreatic Surgery, Translational Medicine Research Center of Liver Cancer, Hunan Province Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan Province 410013, P.R. China.
Man XiaDepartment of Pathology and Laboratory Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA; Laboratory of Digestive Oncology, Hunan Province Cancer Institute, Changsha, Hunan Province 410013, P.R. China.
Yu JiaoDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32611, USA.
Zhouhua HouDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, P.R. China.
Sung JoDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA.
William PuszykDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA.
Kien PhamDepartment of Pathology and Laboratory Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA.
David R NelsonDepartment of Medicine, University of Florida, Gainesville, FL 32611, USA.
Keith RobertsonDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, MN 85259, USA.
David OstrovDepartment of Pathology and Laboratory Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
Pranela RameshwarDepartment of Medicine, Hematology/Oncology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
Chang Qing XiaDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA. Electronic address: xia@pathology.ufl.edu.
Chen LiuDepartment of Pathology and Laboratory Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA. Electronic address: chen.liu@rutgers.edu.
University of Florida · USRutgers, The State University of New Jersey · USHunan Cancer Hospital · CNMayo Clinic in Arizona · USXiangya Hospital Central South University · CN

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Connective tissue growth factor: an intriguing therapeutic target in alcoholic liver diseaseK01AA024174 · NIAAA · UNIVERSITY OF FLORIDA · PI PI, LIYA · 2016 to 2020
$725k
NIAAA NIH HHS K01 AA024174NIA NIH HHS P30 AG028740
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) has a high morbidity and mortality rate worldwide, with limited treatment options. Glypican-3 (GPC3) is a glycosylphosphatidylinositol-anchored glycoprotein that is overexpressed in most HCC tissues but not in normal tissues. GPC3-targeting antibody therapy shows limited response in a clinical trial due to the lack of a tumor-specific cytotoxic T lymphocyte (CTL) response. Here, in C57/B6 mice, we demonstrated that intravenous infusion of GPC3-coupled lymphocytes (LC/GPC3

Indexed as

AnimalsCancer VaccinesCarcinoma, HepatocellularCD8-Positive T-LymphocytesGlypicansInterferon-gammaLiver NeoplasmsMiceMice, Inbred BALB CMice, Inbred C57BLTumor Necrosis Factor-alphaCancer VaccinesGlypicansInterferon-gammaTumor Necrosis Factor-alphacytotoxic T lymphocyte responseglypican-3hepatocellular carcinomaimmunotherapy

Identifiers

PMID28865999
PMCPMC5628867
OpenAlexW2744699281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.