ArticleActa biomaterialia2017
Highly porous scaffolds of PEDOT:PSS for bone tissue engineering.
Article in Acta biomaterialia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advances in Engineering Human Tissue Models.Frontiers in bioengineering and biotechnology · 2020Pooled it
- Low-Cost Ambient Pressure Drying Approach for Highly Porous Nanomaterial Structures.Small methods · 2026Article
- Immunoengineering External Field Responsive Biomaterials for Tissue Repair and Regeneration.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Comparison of 2D, 3DBioengineering (Basel, Switzerland) · 2026Article
- PEDOT:PSS in peripheral nerve injury repair: electrical stimulation, neural interfaces, and neural regenerative mechanisms.Materials today. Bio · 2026Review
- Arbitrary 3D Organic Mixed Ionic-Electronic Conductor Architectures via Self-Fusion of PEDOT:PSS Microfibers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- PEDOT:PSS-A Key Material for Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Evaluating and improving biocompatibility of conductive polymers for cardiac tissue engineering.Journal of materials chemistry. B · 2026Review
- PEDOTs in Bone Tissue Engineering Composites: Fabrication Strategies and Translational Hurdles.Research (Washington, D.C.) · 2026Review
- Reimagining periodontal regeneration: smart biomaterials for a complex tissue landscape.Regenerative biomaterials · 2026Review
- 3D-Printing of Electroconductive MXene-Based Micro-Meshes in a Biomimetic Hyaluronic Acid-Based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Smart and Biodegradable Polymers in Tissue Engineering and Interventional Devices: A Brief Review.Polymers · 2025Review
- Freeze-Dried Porous Collagen Scaffolds for the Repair of Volumetric Muscle Loss Injuries.ACS biomaterials science & engineering · 2025Article
- From innovation to clinic: Emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair.Materials today. Bio · 2025Article
- Cell-free biodegradable electroactive scaffold for urinary bladder tissue regeneration.Nature communications · 2025Article
- Application and progress of 3D printed biomaterials in osteoporosis.Frontiers in bioengineering and biotechnology · 2025Review
- Bone metabolism associated with annual antler regeneration: a deer insight into osteoporosis reversal.Biology direct · 2024Review
- Conductive Microgel Annealed Scaffolds Enhance Myogenic Potential of Myoblastic Cells.Advanced healthcare materials · 2024Article
- Freeze-dried porous collagen scaffolds for the repair of volumetric muscle loss injuries.bioRxiv : the preprint server for biology · 2024Article
- Emerging 2D Nanomaterials-Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conjugated polymers have been increasingly considered for the design of conductive materials in the field of regenerative medicine. However, optimal scaffold properties addressing the complexity of the desired tissue still need to be developed. The focus of this study lies in the development and evaluation of a conductive scaffold for bone tissue engineering. In this study PEDOT:PSS scaffolds were designed and evaluated in vitro using MC3T3-E1 osteogenic precursor cells, and the cells were assessed for distinct differentiation stages and the expression of an osteogenic phenotype. Ice-templated PEDOT:PSS scaffolds presented high pore interconnectivity with a median pore diameter of 53.6±5.9µm and a total pore surface area of 7.72±1.7m STATEMENT OF SIGNIFICANCE: Tissue engineering approaches have been increasingly considered for the repair of non-union fractions, craniofacial reconstruction or large bone defect replacements. The design of complex biomaterials and successful engineering of 3-dimensional tissue constructs is of paramount importance to meet this clinical need. Conductive scaffolds, based on conjugated polymers, present interesting candidates to address the piezoelectric properties of bone tissue and to induce enhanced osteogenesis upon implantation. However, conductive scaffolds have not been investigated in vitro in great measure. To this end, we have developed a highly porous, electrically conductive scaffold based on PEDOT:PSS, and provide evidence that this purely synthetic material is a promising candidate for bone tissue engineering.
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