Evidence map›Paper›PMID 28865985›Full record

ArticleJournal of neuroscience methods2018

Extended, continuous measures of functional status in community dwelling persons with Alzheimer's and related dementia: Infrastructure, performance, tradeoffs, preliminary data, and promise.

Bradley Zylstra, George Netscher, Julien Jacquemot, Michael Schaffer, Galen Shen, Angela D Bowhay, Tamara L Braley, Katherine L Possin, Bruce L Miller, Alexandre M Bayen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  9. Comparisons Between GPS-based and Self-reported Life-space Mobility in Older Adults.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Bradley ZylstraDepartment of Physics, Randolph College, Lynchburg, VA, 24503, USA.
George NetscherDepartment of Civil and Environmental Engineering, University of California, Berkeley, Berkeley, CA, 94720, USA.
Julien JacquemotDepartment of Civil and Environmental Engineering, University of California, Berkeley, Berkeley, CA, 94720, USA.
Michael SchafferMemory and Aging Center, University of California, San Francisco, San Francisco, CA, 94158, USA.
Galen ShenUniversity of Chicago Department of Physics, Chicago, IL, 60637, USA.
Angela D BowhayDepartment of Internal Medicine, Division of Geriatrics, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Tamara L BraleyDepartment of Internal Medicine, Division of Geriatrics, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Katherine L PossinMemory and Aging Center, University of California, San Francisco, San Francisco, CA, 94158, USA.
Bruce L MillerMemory and Aging Center, University of California, San Francisco, San Francisco, CA, 94158, USA.
Alexandre M BayenDepartment of Civil and Environmental Engineering, University of California, Berkeley, Berkeley, CA, 94720, USA.
Stephen J BonaseraDepartment of Internal Medicine, Division of Geriatrics, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address: sbonasera@unmc.edu.
A Katrin SchenkDepartment of Physics, Randolph College, Lynchburg, VA, 24503, USA. Electronic address: kschenk@randolphcollege.edu.
University of California, Berkeley · USUniversity of Nebraska Medical Center · USRandolph College · USUniversity Memory and Aging Center · USUniversity of California, San Francisco · USUniversity of Chicago · US

Funding

Transgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, YADONG · 2004 to 2018
$27.1M
The Care Ecosystem: Navigating patients and caregivers through stages of dementia careR01AG056715 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL · 2017 to 2021
$6.0M
NIA NIH HHS P01 AG017586NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG056715
6 · The paper itself

Abstract

backgroundThe past decades have seen phenomenal growth in the availability of inexpensive and powerful personal computing devices. Efforts to leverage these devices to improve health care outcomes promise to remake many aspects of healthcare delivery, but remain in their infancy. NEW

methodWe describe the development of a mobile health platform designed for daily measures of functional status in ambulatory, community dwelling subjects, including those who have Alzheimer's disease or related neurodegenerative disorders. Using Smartwatches and Smartphones we measure subject overall activity and outdoor location (to derive their lifespace). These clinically-relevant measures allow us to track a subject's functional status in their natural environment over prolonged periods of time without repeated visits to healthcare providers. Functional status metrics are integrated with medical information and caregiver reports, which are used by a caregiving team to guide referrals for physician/APRN/NP care. COMPARISON: with Existing Methods We describe the design tradeoffs involved in all aspects of our current system architecture, focusing on decisions with significant impact on system cost, performance, scalability, and user-adherence.

resultsWe provide real-world data from current subject enrollees demonstrating system accuracy and reliability.

conclusionsWe document real-world feasibility in a group of men and women with dementia that Smartwatches/Smartphones can provide long-term, relevant clinical data regarding individual functional status. We describe the underlying considerations of this system so that interested organizations can adapt and scale our approach to their needs. Finally, we provide a potential agenda to guide development of future systems.

Indexed as

Activities of Daily LivingIndependent LivingAgedAged, 80 and overAlzheimer DiseaseDementiaFemaleHumansMaleMiddle AgedMobile ApplicationsMonitoring, AmbulatorySmartphoneTelemedicineWearable Electronic DevicesActivityAlzheimer’s diseaseDementiaFunctional statusLifespaceSmartphoneSmartwatch

Identifiers

PMID28865985
PMCPMC5832626
OpenAlexW2752349350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.