Evidence map›Paper›PMID 28865877›Full record

ReviewSeminars in immunology2017

Oral immunotherapy for food allergy.

Deborah M Hussey Freeland, Monali Manohar, Sandra Andorf, Benjamin D Hobson, Wenming Zhang, Kari C Nadeau

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Oropharyngeal symptoms without systemic reactions as a risk factor for food allergen intolerance: a longitudinal pediatric study.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022
    Article
  5. AIT: New Avenues in Allergen Immunotherapy.Handbook of experimental pharmacology · 2022
    Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Review
  11. Review
  12. Article
  13. Biomarkers in Food Allergy.Current allergy and asthma reports · 2018
    Review
  14. New treatment directions in food allergy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Deborah M Hussey FreelandSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA 94305, USA; Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA.
Monali ManoharSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA 94305, USA; Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA.
Sandra AndorfSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA 94305, USA; Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA.
Benjamin D HobsonDivision of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA.
Wenming ZhangSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA 94305, USA; Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA.
Kari C NadeauSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA 94305, USA; Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA; Division of Allergy, Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: knadeau@stanford.edu.
Stanford University · US

Funding

Tracking allergen specific T cells in multi-food allergyU19AI104209 · NIAID · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 2013 to 2025
$17.3M
SEAL (Stopping Atopic dermatitis and ALlergy) Study: Prevent allergy by enhancing the skin barrierU01AI147462 · NIAID · STANFORD UNIVERSITY · PI Mary Johnson, GIDEON LACK · 2020 to 2026
$14.0M
NIAID NIH HHS U01 AI147462NIAID NIH HHS U19 AI104209
6 · The paper itself

Abstract

Food allergy is a pathological, potentially deadly cascade of immune responses to molecules or molecular fragments that are normally innocuous when encountered in foods, such as milk, egg, or peanut. As the incidence and prevalence of food allergy rise, the standard of care is poised to advance beyond food allergen avoidance coupled with injectable epinephrine treatment of allergen-induced systemic reactions. Recent studies provide evidence that oral immunotherapy may effectively redirect the atopic immune responses of food allergy patients as they ingest small but gradually increasing allergen doses over many months, eliciting safer immune responses to these antigens. Research into the molecular and cellular bases of pathological and therapeutic immune responses, and into the possibilities for their safe and effective modulation, is generating tremendous interest in basic and clinical immunology. We synthesize developments, innovations, and key challenges in our understanding of the immune mechanisms associated with atopy and oral immunotherapy for food allergy.

Indexed as

Administration, OralAllergensAnimalsDesensitization, ImmunologicEgg Proteins, DietaryFoodFood HypersensitivityHumansAllergensEgg Proteins, DietaryAntigen-specificEpitopeOral food challengeSustained unresponsivenessT helper 2 cellTolerogenic

Identifiers

PMID28865877
PMCPMC5776738
OpenAlexW2750647001

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.