Evidence map›Paper›PMID 28865492›Full record

ArticleBreast cancer research : BCR2017

Pathobiology of the 129:Stat1

Hidetoshi Mori, Jane Q Chen, Robert D Cardiff, Zsófia Pénzváltó, Neil E Hubbard, Louis Schuetter, Russell C Hovey, Josephine F Trott, Alexander D Borowsky

Open access · goldAbstract read
In one paragraph

Article in Breast cancer research : BCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Precision preclinical modeling to advance cancer treatment.Journal of the National Cancer Institute · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. A Syngeneic ErbB2 Mammary Cancer Model for Preclinical Immunotherapy Trials.Journal of mammary gland biology and neoplasia · 2019
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hidetoshi MoriCenter for Comparative Medicine, University of California at Davis, Davis, CA, USA.
Jane Q ChenCenter for Comparative Medicine, University of California at Davis, Davis, CA, USA.
Robert D CardiffCenter for Comparative Medicine, University of California at Davis, Davis, CA, USA.
Zsófia PénzváltóCenter for Comparative Medicine, University of California at Davis, Davis, CA, USA.
Neil E HubbardCenter for Comparative Medicine, University of California at Davis, Davis, CA, USA.
Louis SchuetterCenter for Comparative Medicine, University of California at Davis, Davis, CA, USA.
Russell C HoveyDepartment of Animal Science, University of California at Davis, Davis, CA, USA.
Josephine F TrottDepartment of Animal Science, University of California at Davis, Davis, CA, USA.
Alexander D BorowskyCenter for Comparative Medicine, University of California at Davis, Davis, CA, USA. adborowsky@ucdavis.edu.
University of California, Davis · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9M
Elucidating the molecular and contextual basis for IDLE ultralow risk lesions and the tumor immune microenvironment of high risk in situ and invasive breast cancersU01CA196406 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOROWSKY, ALEXANDER D, ESSERMAN, LAURA J · 2015 to 2020
$5.8M
Translational Insights into Estrogen Receptor alpha-Positive Luminal Breast CanceU01CA141541 · NCI · WASHINGTON UNIVERSITY · PI CARDIFF, ROBERT D, SCHREIBER, ROBERT DAVID · 2009 to 2013
$3.8M
The Center for Translational Genomic PhenotypingU01CA141582 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARDIFF, ROBERT D, CHERRY, SIMON R · 2009 to 2013
$3.5M
NCI NIH HHS P30 CA093373NCI NIH HHS U01 CA141541NCI NIH HHS U01 CA141582NCI NIH HHS U01 CA196406
6 · The paper itself

Abstract

backgroundStat1 gene-targeted knockout mice (129S6/SvEvTac-Stat1

methodsMice housed and treated according to National Institutes of Health guidelines and Institutional Animal Care and Use Committee-approved methods were evaluated by histopathology, and their tissues were subjected to immunohistochemistry with computer-assisted quantitative image analysis. Tumor cell culture and conditioned media from cell culture were used to perform macrophage (RAW264.7) cell migration assays, including the 129:Stat1

resultsTumorigenesis in 129:Stat1

conclusions129:Stat1

Indexed as

PhenotypeAge FactorsAnimalsBreast NeoplasmsChemotaxis, LeukocyteDisease Models, AnimalFemaleHumansImmunohistochemistryIncidenceMacrophagesMammary Neoplasms, ExperimentalMiceMice, 129 StrainMice, KnockoutReceptors, EstrogenReceptors, EstrogenSTAT1 Transcription FactorEstrogen receptorLuminal breast cancerPathobiologyStat1-knockout mouseTumor immunologyTumor microenvironment

Identifiers

PMID28865492
PMCPMC5581425
OpenAlexW2751614562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.