ArticleBMC geriatrics2017
Association between life-course socioeconomic position and inflammatory biomarkers in older age: a nationally representative cohort study in Taiwan.
Article in BMC geriatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- The intergenerational effects of low parental socio-economic position on cardiometabolic and inflammatory outcomes: A systematic review and meta-analysis.European journal of clinical investigation · 2026Pooled it
- Allostatic Load and Exposure Histories of Disadvantage.International journal of environmental research and public health · 2021Article
- Dissecting the genetic association of C-reactive protein with PTSD, traumatic events, and social support.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Plasma Arginase-1 Level Is Associated with the Mental Status of Outpatients with Chronic Liver Disease.Diagnostics (Basel, Switzerland) · 2021Article
- Multi-cohort study identifies social determinants of systemic inflammation over the life course.Nature communications · 2019Article
- Psychological Stress During Childhood and Adolescence and Its Association With Inflammation Across the Lifespan: A Critical Review and Meta-Analysis.Psychological bulletinArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundEvidence of an association between low socioeconomic position (SEP) and inflammatory markers is scant. This study aimed to examine how life-course SEP predicted C-reactive protein (CRP) and interleukin (IL-6) in older age from a national cohort.
methodsWe collected data from 1036 participants in the Social Environment and Biomarkers of Aging Study in Taiwan. Four SEP time points, childhood, young adulthood, active professional life, and older age were measured retrospectively. A group-based trajectory analysis method was used to identify the distinct trajectories of life-course SEP, and trajectory group membership was used as the predictor of CRP and IL-6 levels in older age.
resultsThree trajectories of life-course SEP were identified within the total sample: Low-Low (36.5%), Low-High (26.8%), and High-High (36.7%). Participants in the High-High group had the lowest levels of CRP and IL-6. Compared with those in the Low-Low group, the participants in the Low-High group had a similar adjusted CRP [-0.032 ln mg/L; 95% confidence interval (CI) - 0.193, 0.128] and IL-6 (0.017 ln pg/mL; 95% CI -0.093, 0.128); the participants in the High-High group had a significantly lower level of adjusted CRP concentration (-0.279 ln mg/L; 95% CI: -0.434, -0.125) and similarly lower IL-6 concentration (-0.129 ln pg/mL; 95% CI -0.236, -0.023) .
conclusionsLife-course SEP is related to the level of CRP and IL-6 in older age. Our data support the notion that life-course SEP predicts inflammatory markers in older age. Low SEP in childhood is related to elevated inflammatory markers in older age. Even after the transition from low SEP in childhood to high SEP in older age, the risk remains. Further study on SEP and inflammation-related disease is warranted.
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