ArticleBMC musculoskeletal disorders2017
Silver-coated modular Megaendoprostheses in salvage revision arthroplasty after periimplant infection with extensive bone loss - a pilot study of 34 patients.
Article in BMC musculoskeletal disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Management of infected periprosthetic fracture of hip and knee: a systematic review of the literature.EFORT open reviews · 2026Pooled it
- Comparative effectiveness of antimicrobial implant surface coatings in preventing orthopaedic implant-associated infections: a network meta-analysis.Archives of orthopaedic and trauma surgery · 2026Pooled it
- Potential side effects of antibacterial coatings in orthopaedic implants: A systematic review of clinical studies.Frontiers in bioengineering and biotechnology · 2023Pooled it
- Silver-coated megaprosthesis in prevention and treatment of peri-prosthetic infections: a systematic review and meta-analysis about efficacy and toxicity in primary and revision surgery.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2021Pooled it
- Functional Outcomes and Complications of Megaprosthetic Reconstruction in Limb-Salvage Surgery for Musculoskeletal Tumors: A Scoping Review.Journal of orthopaedic case reports · 2026Review
- Silver integrated hybrids and nanocomposites for next-generation biomedicine: Beyond antimicrobial coatings toward smart sense-response-heal platforms.Materials today. Bio · 2025Review
- Evaluation of Zimmer® segmental distal femur mega-prostheses: Patient survival, surgical outcomes and functional outcome.Journal of bone oncology · 2025Article
- Effects of Implant Silver Coatings on Bone Formation in Animal Models: A Systematic Review and Meta-Analysis.Journal of functional biomaterials · 2025Review
- Unconventional Therapies in Periprosthetic Joint Infections: Prevention and Treatment: A Narrative Review.Journal of clinical medicine · 2025Review
- Comparative effectiveness of silver-coated implants in periprosthetic infection prevention: A systematic review and meta-analysis.Journal of orthopaedics · 2025Review
- Modular megaprostheses yield high any-type failure rate but acceptable infection control rate in patients with chronic hip and knee periprosthetic joint infection and severe bone loss: a single-center experience.Journal of bone and joint infection · 2025Article
- Are silver-coated megaprostheses superior to uncoated megaprostheses in managing chronic end-stage periprosthetic hip and knee infection?Archives of orthopaedic and trauma surgery · 2024Article
- Use of a silver-coated plate to treat a postoperative infection after high tibial osteotomy - a case report.Journal of bone and joint infection · 2024Article
- Silver-Coated Distal Femur Megaprosthesis in Chronic Infections with Severe Bone Loss: A Multicentre Case Series.Journal of clinical medicine · 2023Article
- Management of complications of mega-implants following treatment of primary and periprosthetic fractures of the lower extremities.Scientific reports · 2023Article
- Megaprosthesis in Non-Oncologic Settings-A Systematic Review of the Literature.Journal of clinical medicine · 2023Review
- Staged Management of Infection with Adjustable Spacers After Megaprosthesis Implantation in Primary Sarcoma Patients.Indian journal of orthopaedics · 2023Article
- Knee Arthrodesis with a Modular Silver-Coated Endoprosthesis for Infected Total Knee Arthroplasty with Extensive Bone Loss: A Retrospective Case-Series Study.Journal of clinical medicine · 2023Article
- Prosthetic Joint Infection in Mega-Arthroplasty Following Shoulder, Hip and Knee Malignancy-A Prospective Follow-Up Study.Life (Basel, Switzerland) · 2022Article
- Long-term changes in serum silver concentrations after extremity reconstruction with silver-coated megaprostheses.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHip and knee replacements in patients with bone defects after infection correlates with high rates of reinfection. In this vulnerable patient population, the prevention of reinfection is to be considered superordinate to the functionality and defect bridging. The use of silver coating of aseptic implants as an infection prophylaxis is already proven; however, the significance of these coatings in septic reimplantation of large implants is still not sufficiently investigated.
methodsIn a retrospective analysis, 34 patients who have been treated with a modular mega-endoprosthesis after a cured bone infection of the lower limb (femur or tibia) have been evaluated. One group with 14 patients (NSCG: non silver- coated group) was supplied with the non silver- coated implants: MML München- Lübeck™ modular endoprosthesis system (AQ Implants, Ahrensburg, Germany) or MUTARS® Modular Universal Tumor And Revision System (Implantcast GmbH, Buxtehude, Germany). The other group with 20 patients (SCG: silver- coated group) was supplied with the silver- coated system of MUTARS®. In addition to the clinical findings and the patients' histories, specifically the reinfection rates, the patients' mobility was assessed using the New Mobility Score (NMS, by Parker and Palmer).
resultsThe median follow-up period was 72 months, ranging from 6 to 267 months. The dropout rate was 5.8%. The reinfection rate after healed reinfection in SCG was 40% (8/20), in NSCG 57% (8/14), p = 0.34; α =0.05. The time for reinfection was, on average, 14 months (1-72 months) in SCG and 8 months (1-48 months) in the NSCG (p = 0.61; α =0.05). The two groups showed no differences in the NMS.
conclusionWith this retrospective analysis, it can be determined that the rate of reinfection of modular mega-endoprostheses on the hip and knee joint after healed periprosthetic joint infection (PJI) can be reduced by the use of silver coated implants. The time until reinfection can also be delayed by utilizing silver coated implants. Due to the low number of cases of this highly specific patient population, no statistical significance could be determined. A positive effect, however, can be assumed through the use of silver coatings in mega-endoprostheses after an infectious situation.
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