ArticleActa psychiatrica Scandinavica2017
Resting state perfusion in the language network is linked to formal thought disorder and poor functional outcome in schizophrenia.
Article in Acta psychiatrica Scandinavica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Neurovascular Uncoupling in Schizophrenia: A Bimodal Meta-Analysis of Brain Perfusion and Glucose Metabolism.Frontiers in psychiatry · 2020Pooled it
- Visualizing pain-processing networks with 7T resting-state functional MRI using pseudo-continuous arterial spin labeling.Scientific reports · 2026Article
- The hippocampal-cortical system cerebral blood flow in schizophrenia: Primary disease versus antipsychotic medication effects.Schizophrenia research · 2026Article
- Differential structural cortical correlates of positive, negative, and linguistic control formal thought disorder dimensions in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Schizophasia and Cognitive Impairment in Schizophrenia: A Literature Review.Brain sciences · 2024Review
- The Neurobiology of Formal Thought Disorder.Current topics in medicinal chemistry · 2024Review
- Predicting new onset thought disorder in early adolescence with optimized deep learning implicates environmental-putamen interactions.medRxiv : the preprint server for health sciences · 2023Article
- Resting-state perfusion in motor and fronto-limbic areas is linked to diminished expression of emotion and speech in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Neural Correlates of Formal Thought Disorder Dimensions in Psychosis.Schizophrenia bulletin · 2023Article
- Flights and Perchings of the BrainMind: A Temporospatial Approach to Psychotherapy.Frontiers in psychology · 2022Article
- Genetic Intersections of Language and Neuropsychiatric Conditions.Current psychiatry reports · 2020Review
- Prediction of early response to overall treatment for schizophrenia: A functional magnetic resonance imaging study.Brain and behavior · 2019Article
- Resting state perfusion in the language network is linked to formal thought disorder and poor functional outcome in schizophrenia.Acta psychiatrica Scandinavica · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFormal thought disorder (FTD) is a core symptom in schizophrenia. Here, we focus on resting state cerebral blood flow (rCBF) linked to dimensions of FTD.
methodsWe included 47 schizophrenia spectrum patients and 30 age- and gender-matched healthy controls. We assessed FTD with the assessment of thought, language, and communication (TLC) and imaging on a 3T MRI scanner. Within patients, we tested the association of FTD dimensions and in a subgroup (n = 27) the association of functional outcome after 6 months with whole brain rCBF.
resultsNegative FTD was most prominently associated with perfusion within the superior temporal gyrus, while positive FTD was associated with perfusion within the supplementary motor area, and inferior frontal gyrus. Perfusion within the left supramarginal gyrus was associated with social functioning after 6 months.
conclusionsDistinguishable associations of rCBF with FTD dimensions point to distinct underlying pathophysiology. The location of aberrant perfusion patterns suggests that negative FTD might reflect defective access to semantic memory while positive FTD likely reflects defective suppression of irrelevant information during increased speech production. Finally, the neural correlates of thought block were also predictive of poor functional outcome. Thus, functional outcome and distinct FTD dimensions may share some pathophysiology.
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