ArticleActa psychiatrica Scandinavica2017
The role of stress-regulation genes in moderating the association of stress and daily-life psychotic experiences.
Article in Acta psychiatrica Scandinavica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Oxytocin dysfunction in severe mental illnesses following adverse childhood experiences: a systematic review.BMC psychiatry · 2026Pooled it
- Methodological Characteristics and Feasibility of Ecological Momentary Assessment Studies in Psychosis: a Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2024Pooled it
- Thoughts Falling Apart: Disorganized Schizotypy Specifically Predicts Both Psychotic- and Stress-Reactivity in Daily Life.Journal of personality · 2026Article
- Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life.Schizophrenia bulletin · 2025Article
- The Interaction of Polygenic Susceptibility to Stress and Childhood Adversity Dimensions Predicts Longitudinal Trajectories of Stress-Sensitivity.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- Article
- Positive schizotypy is associated with amplified mnemonic discrimination and attenuated generalization.European archives of psychiatry and clinical neuroscience · 2023Article
- Psychological Pathways to Paranoia and Psychotic-Like Experiences in Daily-Life: The Mediating Role of Distinct Affective Disturbances.Schizophrenia bulletin · 2022Article
- COVID-19 dimensions and psychotic experiences among US college students: Findings from the Healthy Mind Study 2020.Schizophrenia research · 2021Article
- Article
- Changes in psychotic-like experiences and related influential factors in technical secondary school and college students during COVID-19.Schizophrenia research · 2021Article
- The Impact of theBrain sciences · 2021Article
- Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness.Acta psychiatrica Scandinavica · 2020Article
- Interaction of both positive and negative daily-life experiences withEuropean psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- The role of stress-regulation genes in moderating the association of stress and daily-life psychotic experiences.Acta psychiatrica Scandinavica · 2017Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe interaction of single nucleotide polymorphisms with both distal and proximal environmental factors across the extended psychosis phenotype is understudied. This study examined (i) the interaction of relevant SNPs with both early-life adversity and proximal (momentary) stress on psychotic experiences (PEs) in an extended psychosis sample; and (ii) differences between early-psychosis and non-clinical groups for these interactions.
methodsTwo hundred and forty-two non-clinical and 96 early-psychosis participants were prompted randomly eight times daily for 1 week to complete assessments of current experiences, including PEs and stress. Participants also reported on childhood trauma and were genotyped for 10 SNPs on COMT, RGS4, BDNF, FKBP5, and OXTR genes.
resultsUnlike genetic variants, distal and proximal stressors were associated with PEs in both samples and were more strongly associated with PEs in the early-psychosis than in the non-clinical group. The RGS4 TA and FKBP5 CATT haplotypes interacted with distal stress, whereas the A allele of OXTR (rs2254298) interacted with proximal stress, increasing momentary levels of PEs in the early-psychosis group. No interactions emerged with COMT or BDNF variants.
conclusionIndividual differences in relevant stress-regulation systems interact with both distal and proximal psychosocial stressors in shaping the daily-life manifestation of PEs across the psychosis continuum.
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