Evidence map›Paper›PMID 28865391›Full record

ArticleDrug and alcohol dependence2017

Discriminative stimulus and locomotor effects of para-substituted and benzofuran analogs of amphetamine.

Sean B Dolan, Michael J Forster, Michael B Gatch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. (2-Aminopropyl)benzo[β]thiophenes (APBTs) are novel monoamine transporter ligands that lack stimulant effects but display psychedelic-like activity in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  6. Article
  7. Review
  8. Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sean B DolanUniversity of North Texas Health Science Center, Center for Neuroscience Discovery, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States.
Michael J ForsterUniversity of North Texas Health Science Center, Center for Neuroscience Discovery, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States.
Michael B GatchUniversity of North Texas Health Science Center, Center for Neuroscience Discovery, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States. Electronic address: michael.gatch@unthsc.edu.
University of North Texas · USUniversity of North Texas Health Science Center · US

Funding

Training in the Neurobiology of Aging and Alzheimer's DiseaseT32AG020494 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ROBERT Clinton BARBER, NATHALIE SUMIEN · 2002 to 2026
$6.9M
NIA NIH HHS T32 AG020494NIDA NIH HHS HHSN271201300001C
6 · The paper itself

Abstract

Novel psychoactive substances have maintained a prominent role in the global drug culture, despite increased regulation by governing bodies. Novel compounds continue to become available on the market, often in "Ecstasy" or "Molly" formulations in lieu of MDMA, at a much faster rate than they can be properly characterized. The current study aimed to investigate the discriminative stimulus and locomotor effects of three putatively entactogenic compounds that have become increasingly prevalent on the drug market: 5-(2-aminopropyl)-benzofuran (5-APB), 6-(2-aminopropryl)-2,3-dihydrobenzofuran (6-APDB), and 4-fluoroamphetamine (4-FA). Locomotor stimulant effects were assessed in an open-field assay for locomotor activity using Swiss-Webster mice. Discriminative stimulus effects were assessed in Sprague-Dawley rats trained to discriminate either cocaine, methamphetamine, DOM, or MDMA from vehicle. The benzofuran compounds produced locomotor stimulation whereas 4-FA depressed locomotor activity. The benzofurans substituted for the discriminative stimulus effects of MDMA, but only partially or not at all for methamphetamine, cocaine, and DOM, whereas 4-FA fully substituted for MDMA, methamphetamine and cocaine, but not DOM. These results indicate an MDMA-like pattern of abuse might be expected for the benzofurans, whereas 4-FA may be substituted for psychostimulants and MDMA.

Indexed as

AmphetamineAmphetaminesAnimalsBenzofuransCentral Nervous System StimulantsCocaineDiscrimination LearningDose-Response Relationship, DrugLocomotionMaleMethamphetamineMiceN-Methyl-3,4-methylenedioxyamphetamineRatsRats, Sprague-Dawley4-fluoroamphetamineAmphetamineAmphetaminesBenzofuransCentral Nervous System StimulantsCocaineMethamphetamineN-Methyl-3,4-methylenedioxyamphetamineAmphetamineBenzofuranDrug discriminationRat

Identifiers

PMID28865391
PMCPMC6463889
OpenAlexW2746058256

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.