Evidence map›Paper›PMID 28865344›Full record

ArticleVirology2017

Heartland virus infection in hamsters deficient in type I interferon signaling: Protracted disease course ameliorated by favipiravir.

Jonna B Westover, Johanna D Rigas, Arnaud J Van Wettere, Rong Li, Brady T Hickerson, Kie-Hoon Jung, Jinxin Miao, Erin S Reynolds, Bettina L Conrad, Skot Nielson and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Jonna B WestoverUtah State University, 5600 Old Main Hill, Logan, UT 84322, USA.
Johanna D RigasUtah State University, 5600 Old Main Hill, Logan, UT 84322, USA; Utah Veterinary Diagnostic Laboratory, 950 E. 1400 N., Logan, UT 84341, USA.
Arnaud J Van WettereUtah State University, 5600 Old Main Hill, Logan, UT 84322, USA; Utah Veterinary Diagnostic Laboratory, 950 E. 1400 N., Logan, UT 84341, USA.
Rong LiUtah State University, 5600 Old Main Hill, Logan, UT 84322, USA.
Brady T HickersonUtah State University, 5600 Old Main Hill, Logan, UT 84322, USA.
Kie-Hoon JungUtah State University, 5600 Old Main Hill, Logan, UT 84322, USA.
Jinxin MiaoUtah State University, 5600 Old Main Hill, Logan, UT 84322, USA; Zhengzhou University, 100 Kexue Ave., Zhengzhou Shi, Henan Sheng, People's Republic of China.
Erin S ReynoldsUniversity of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA.
Bettina L ConradUtah Veterinary Diagnostic Laboratory, 950 E. 1400 N., Logan, UT 84341, USA.
Skot NielsonUtah State University, 5600 Old Main Hill, Logan, UT 84322, USA.
Yousuke FurutaResearch Laboratories, Toyama Chemical Co., Ltd., Toyama 930-8508, Japan.
Saravanan ThangamaniUniversity of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA.
Zhongde WangUtah State University, 5600 Old Main Hill, Logan, UT 84322, USA.
Brian B GowenUtah State University, 5600 Old Main Hill, Logan, UT 84322, USA. Electronic address: brian.gowen@usu.edu.
Utah State University · USThe University of Texas Medical Branch at Galveston · USToyama College · JP

Funding

Development of a Tick Transmission Model for Heartland Virus PathogenesisR21AI113128 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI THANGAMANI, SARAVANAN · 2015 to 2016
$426k
NIAID NIH HHS HHSN272201000039CNIAID NIH HHS HHSN272201000039INIAID NIH HHS R21 AI113128
6 · The paper itself

Abstract

Heartland virus (HRTV) is an emerging tick-borne virus (Bunyaviridae, Phlebovirus) that has caused sporadic cases of human disease in several central and mid-eastern states of America. Animal models of HRTV disease are needed to gain insights into viral pathogenesis and advancing antiviral drug development. Presence of clinical disease following HRTV challenge in hamsters deficient in STAT2 function underscores the important role played by type I interferon-induced antiviral responses. However, the recovery of most of the infected animals suggests that other mechanisms to control infection and limit disease offer substantial protection. The most prominent disease sign with HRTV infection in STAT2 knockout hamsters was dramatic weight loss with clinical laboratory and histopathology demonstrating acute inflammation in the spleen, lymph node, liver and lung. Finally, we show that HRTV disease in hamsters can be prevented by the use of favipiravir, a promising broad-spectrum antiviral in clinical development for the treatment of influenza.

Indexed as

AmidesAnimalsAnimal StructuresAntiviral AgentsBunyaviridae InfectionsChemopreventionCricetinaeDisease Models, AnimalInflammationInterferon Type IPyrazinesSTAT2 Transcription FactorTreatment OutcomeAmidesAntiviral AgentsfavipiravirInterferon Type IPyrazinesStat2 protein, mouseSTAT2 Transcription FactorAnimal modelFavipiravirHeartland virusPhlebovirusSevere fever with thrombocytopenia syndrome virusType I interferon

Identifiers

PMID28865344
PMCPMC5623653
OpenAlexW2752077543

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.