Evidence map›Paper›PMID 28865065›Full record

Trial reportClinical oral investigations2018

Fluoride in saliva and dental biofilm after 1500 and 5000 ppm fluoride exposure.

Line Staun Larsen, Vibeke Baelum, Livia Maria Andaló Tenuta, Alan Richards, Bente Nyvad

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Line Staun LarsenSection of Dental Pathology, Operative Dentistry and Endodontics, Department of Dentistry and Oral Health, HEALTH, Aarhus University, Vennelyst Boulevard 9, 8000, Aarhus C, Denmark. line.staun@dent.au.dk.ORCID http://orcid.org/0000-0002-4155-5884
Vibeke BaelumSection of Oral Epidemiology and Dental Public Health, Department of Dentistry and Oral Health, HEALTH, Aarhus University, Vennelyst Boulevard 9, 8000, Aarhus C, Denmark.
Livia Maria Andaló TenutaDepartment of Physiological Sciences, Piracicaba Dental School, UNICAMP, Av. Limeira 901, Piracicaba, São Paulo, 13414-903, Brazil.
Alan RichardsSection of Dental Pathology, Operative Dentistry and Endodontics, Department of Dentistry and Oral Health, HEALTH, Aarhus University, Vennelyst Boulevard 9, 8000, Aarhus C, Denmark.
Bente NyvadSection of Dental Pathology, Operative Dentistry and Endodontics, Department of Dentistry and Oral Health, HEALTH, Aarhus University, Vennelyst Boulevard 9, 8000, Aarhus C, Denmark.
Aarhus University · DKUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this randomized, double-blind, crossover study was to measure fluoride in saliva and 7-day-old biofilm fluid and biofilm solids after rinsing three times per day for 3 weeks with 0, 1500, or 5000 ppm fluoride (NaF). MATERIALS AND

methodsFollowing the 3-week wash-in/wash-out period, including 1 week of biofilm accumulation, saliva and biofilm samples were collected from 12 participants immediately before (background fluoride), and 10, 30, and 60 min after a single rinse. Biofilm samples were separated into fluid and solids, and samples were analyzed using a fluoride electrode (microanalysis).

resultsThe background fluoride concentration was statistically significantly higher in the 5000 compared to the 1500 ppm F rinse group in all three compartments (22.3 and 8.1 μM in saliva, 126.8 and 58.5 μM in biofilm fluid, and 10,940 and 4837 μmol/kg in biofilm solids). The 1-h fluoride accumulation for the 5000 ppm F rinse was higher than for the 1500 ppm F rinse in all three compartments, although not statistically significant for saliva and biofilm solids.

conclusionRegular exposure to 5000 ppm fluoride elevates background fluoride concentrations in saliva, biofilm fluid, and biofilm solids compared to 1500 ppm fluoride. Increasing the fluoride concentration almost 3.5 times (from 1500 to 5000 ppm) only elevates the background fluoride concentrations in saliva, biofilm fluid, and biofilm solids twofold. CLINICAL RELEVANCE: Even though fluoride toothpaste may be diluted by saliva, the results of the present study indicate that use of 5000 ppm fluoride toothpaste might lead to improved caries control.

Indexed as

AdultBiofilmsCross-Over StudiesDouble-Blind MethodFemaleFluoridesHumansMouthwashesSalivaToothpastesFluoridesMouthwashesToothpastesBiofilm fluidBiofilm solidsDental cariesDental plaqueFluoridesSaliva

Identifiers

PMID28865065
OpenAlexW2752714289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.