Evidence map›Paper›PMID 28864949›Full record

ArticleEuropean journal of applied physiology2017

Skeletal muscle mitochondrial mass is linked to lipid and metabolic profile in individuals with spinal cord injury.

Laura C O'Brien, Qun Chen, Jeannie Savas, Edward J Lesnefsky, Ashraf S Gorgey

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of applied physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01652040 (Effects of Evoked Resistance Training and Testosterone After Spinal Cord Injury), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01652040 phase2 / phase3completednot on this map

Effects of Evoked Resistance Training and Testosterone After Spinal Cord Injury

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2012 to 2017Enrolled26ConditionsSpinal Cord InjuryArmsResistance Training and Testosterone Patches, Testosterone Patches
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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  17. Mitochondrial health and muscle plasticity after spinal cord injury.European journal of applied physiology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Laura C O'BrienSpinal Cord Injury Research, Spinal Cord Injury and Disorders Service, Hunter Holmes McGuire VA Medical Center, 1201 Broad Rock Blvd, Richmond, VA, 23249, USA.
Qun ChenDivision of Cardiology, Department of Medicine, Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Jeannie SavasSurgery, Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA.
Edward J LesnefskyDepartment of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA.
Ashraf S GorgeySpinal Cord Injury Research, Spinal Cord Injury and Disorders Service, Hunter Holmes McGuire VA Medical Center, 1201 Broad Rock Blvd, Richmond, VA, 23249, USA. ashraf.gorgey@va.gov.
Hunter Holmes McGuire VA Medical Center · USVirginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChanges in metabolism and body composition after spinal cord injury (SCI) predispose individuals to obesity, type II diabetes, and cardiovascular disease. A link between lean mass and skeletal muscle mitochondrial mass has been reported but it is unknown how skeletal muscle mitochondrial mass and activity impact metabolic health. This study examined the relationship between skeletal muscle mitochondrial mass, activity and metabolic profile in individuals with chronic SCI.

methodsTwenty-two men with motor complete SCI participated in the study. Citrate synthase (CS) and complex III (CIII) activity was measured in vastus lateralis biopsies. Metabolic profile was assessed by intravenous glucose tolerance test, basal metabolic rate (BMR), maximum oxygen uptake (VO

resultsSkeletal muscle CS activity was negatively related to the cholesterol:high density lipoprotein cholesterol (HDL-C) ratio and triglycerides (r = -0.60, p = 0.009; r = -0.64, p = 0.004, respectively). CS activity was positively related to insulin sensitivity and BMR (r = 0.67, p = 0.006; r = 0.64, p = 0.005, respectively). Similar relationships were found for CIII and metabolic profile, but not CIII normalized to CS. Many of the relationships between CS and metabolism remained significant when age, level of injury, or time since injury were accounted for. They also remained significant when CS activity was normalized to total lean mass.

conclusionsThese results suggest that an increase in skeletal muscle mitochondrial mass is associated with improved metabolic health independent of age, level of injury, or time since injury in individuals with chronic SCI. This highlights the importance of maintaining and improving mitochondrial health in individuals with SCI.

Indexed as

Lipid MetabolismAdolescentAdultBlood GlucoseCitrate (si)-SynthaseElectron Transport Complex IIIHumansMaleMiddle AgedMitochondria, MuscleMuscle, SkeletalOxygen ConsumptionSpinal Cord InjuriesBlood GlucoseCitrate (si)-SynthaseElectron Transport Complex IIICholesterolLipid profileMetabolismMitochondriaSkeletal muscleSpinal cord injury

Identifiers

PMID28864949
OpenAlexW2753701102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.