ArticleWiener klinische Wochenschrift2017
Charlson Comorbidity Index, inappropriate medication use and cognitive impairment : Bermuda Triangle.
Article in Wiener klinische Wochenschrift, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Association between social capital and trajectories of cognitive function among Chinese older adults.BMC public health · 2025Article
- Risk factors and prediction model for cancer-related cognitive impairment in thyroid cancer patients.American journal of cancer research · 2025Article
- Toward a Medication Information Literacy Indicator System for Older Adults: A Delphi Study.Health expectations : an international journal of public participation in health care and health policy · 2024Article
- Impact of Comorbidities on the Risk of Polypharmacy and Potentially Inappropriate Medications in Older Patients.Journal of general internal medicine · 2024Article
- Prevalence and factors associated with polypharmacy among patients with rheumatoid arthritis: a single-centre, cross-sectional study.Clinical rheumatology · 2023Article
- Overuse of medications in low- and middle-income countries: a scoping review.Bulletin of the World Health Organization · 2023Article
- Predictivity of the comorbidity indices for geriatric syndromes.BMC geriatrics · 2022Article
- Critical role of acute hypoxemia on the cognitive impairment after severe COVID-19 pneumonia: a multivariate causality model analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Observational
- The comorbidity conditions and polypharmacy in elderly patients with mental illness in a middle income country: a cross-sectional study⋆.IBRO reports · 2020Article
- Mild Cognitive Impairment that Does Not Progress to Dementia: A Population-Based Study.Journal of the American Geriatrics Society · 2019Article
- The Association between Polypharmacy and Hip Fracture in Osteoporotic Women: A Nested Case-Control Study in South Korea.Clinical drug investigation · 2019Article
- Prevalence of Cognitive Impairment and Association With Survival Among Older Patients With Hematologic Cancers.JAMA oncology · 2018Article
- Cross-sectional Associations of Fatigue with Cerebral β-Amyloid in Older Adults at Risk of Dementia.Frontiers in medicine · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim is to evaluate the association between the Charlson Comorbidity Index (CCI), polypharmacy, inappropriate medication use and cognitive impairment in long-term care facility patients.
methodsA cross-sectional study including 105 long-term care facility residents was performed. The Charlson Comorbidity Index (CCI) was used. Inappropriate drug use (IDU) was defined according to the STOPP (Screening Tool of Older People's Prescriptions) criteria. Univariate analysis to identify variables associated with patient outcome related with cognitive impairment was investigated with χ
resultsA significant difference was found between gender, CCI and cognitive impairment (p = 0.038, p = 0.01). While every one point increment in the CCI increases the risk of cognitive impairment 3.1 fold (95% CI = 1.8-5.4, p < 0.001), hypertension increases the risk 12 fold (95% CI = 2.5-67.8, p = 0.002). While the correlation between Mini-Mental Status Examination (MMSE) score and polypharmacy is significant (p = 0.015), the correlation between MMSE and IDU was insignificant (p = 0.739). The association of urogenital system drugs and dementia was significant (p = 0.044).
conclusionsComorbidities, especially hypertension and old age, are risk factors for cognitive impairment. Polypharmacy correlates with MMSE and is considered a risk factor for cognitive impairment. Inappropriate medication use is high among long-term care facility residents. More studies on large cohorts are needed regarding optimal drug prescription and detection of specific drugs that may have an impact on cognitive performance.
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