ArticleBioscience reports2017
Ozone oil promotes wound healing by increasing the migration of fibroblasts via PI3K/Akt/mTOR signaling pathway.
Article in Bioscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it, 167 citations in OpenAlex.
- Mechanism and clinical application of ozone therapy in treating skin ulcer diseases.Medical gas research · 2026Pooled it
- Liquid ozone therapies for the treatment of epithelial wounds: A systematic review and meta-analysis.International wound journal · 2023Pooled it
- Medical Gas Therapy for Tissue, Organ, and CNS Protection: A Systematic Review of Effects, Mechanisms, and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Pooled it
- Effect of Adjunctive Ozone Application Protocols on Dentin-Derived Growth Factor Release: An In Vitro Study.Journal of clinical medicine · 2026Article
- Impact of oxygen-ozone mixture on cellular functions: a biochemical perspective across cell types.Molecular medicine (Cambridge, Mass.) · 2026Review
- One-Step Coaxial 3D Printing of Pre-Vascularized Skin Organoid Models with ADSC Microspheres for Enhanced Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Potential of Ozone Therapy as an Adjunct to Periodontal Treatment in Diabetes Mellitus: A Biomarkers Scoping Review.Current diabetes reviews · 2026Article
- Ozone protects against ischemia-reperfusion injury: molecular mechanisms.Frontiers in pharmacology · 2026Review
- Ozonated olive oil inhibits melanoma proliferation by inducing ferroptosis.Biochemistry and biophysics reports · 2025Article
- Ozonized Sunflower Oil: Standardization and Mechanisms of the Antimicrobial Effect.International journal of molecular sciences · 2025Article
- Nanocarriers for Medical Ozone Delivery: A New Therapeutic Strategy.Nanomaterials (Basel, Switzerland) · 2025Review
- Targeting diabetic foot ulcer pathophysiology: altered signaling pathways and 3D scaffold as an emerging treatment strategy.3 Biotech · 2025Review
- Piezoelectric dual-network tough hydrogel with on-demand thermal contraction and sonopiezoelectric effect for promoting infected-joint-skin-wound healing via FAK and AKT signaling pathways.National science review · 2025Article
- Mesenchymal stem cells and their exosomes: a novel approach to skin regeneration via signaling pathways activation.Journal of molecular histology · 2025Review
- Review
- Single-Cell Multiomics Analysis of Early Wound Response Programs in the Mouse Corneal Epithelium.Investigative ophthalmology & visual science · 2025Article
- Evaluating the therapeutic efficacy of ozone liquid dressing in healing wounds associated with bullous pemphigoid.Scientific reports · 2025Article
- The Impact of Ozone on Periodontal Cell Line Viability and Function.Current issues in molecular biology · 2025Review
- Effect of ozone oil and non-surgical periodontal treatment in patients with type 2 diabetes. In-vivo and in-vitro studies with fibroblasts and Candida albicans.Journal of applied oral science : revista FOB · 2025Article
- The role of glucose metabolism in wound healing: an overview.Burns & trauma · 2025Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin injury affects millions of people via the uncontrolled inflammation and infection. Many cellular components including fibroblasts and signaling pathways such as transforming growth factor-β (TGF-β) were activated to facilitate the wound healing to repair injured tissues. C57BL/6 female mice were divided into control and ozone oil treated groups. Excisional wounds were made on the dorsal skin and the fibroblasts were isolated from granulation tissues. The skin injured mouse model revealed that ozone oil could significantly decrease the wound area and accelerate wound healing compared with control group. QPCR and Western blotting assays showed that ozone oil up-regulated
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.