ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018
A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- GPAM mediates mitochondrial dysfunction and the progression of alcoholic liver disease through lipid remodeling.Science advances · 2026Article
- Emerging roles and therapeutic implications of lipid droplet protein perilipin 2 in liver disease.Genes & diseases · 2026Review
- A missense variant in human perilipin 2 (JHEP reports : innovation in hepatology · 2024Article
- The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease.Nature reviews. Gastroenterology & hepatology · 2023Review
- Article
- Growth-Promoting Effects of Zhenqi Granules on Finishing Pigs.Animals : an open access journal from MDPI · 2022Article
- Absolute quantitative lipidomics reveals lipids profiling in liver of mice with early-stage alcoholic liver disease.Nutrition & metabolism · 2022Article
- Ceramide synthase 6 mediates sex-specific metabolic response to dietary folic acid in mice.The Journal of nutritional biochemistry · 2021Article
- Imipramine Accelerates Nonalcoholic Fatty Liver Disease, Renal Impairment, Diabetic Retinopathy, Insulin Resistance, and Urinary Chromium Loss in Obese Mice.Veterinary sciences · 2021Article
- Novel Targets in Glucose Homeostasis and Obesity-Lesson from Rare Mutations.Current diabetes reports · 2020Review
- Summary of the 2019 alcohol and immunology research interest group (AIRIG) meeting: Alcohol-mediated mechanisms of multiple organ injury.Alcohol (Fayetteville, N.Y.) · 2020Review
- Liver-specific ceramide reduction alleviates steatosis and insulin resistance in alcohol-fed mice.Journal of lipid research · 2020Article
- Sphingolipids and the link between alcohol and cancer.Chemico-biological interactions · 2020Review
- Alcohol effects on hepatic lipid metabolism.Journal of lipid research · 2020Review
- Rapid Lipid Droplet Isolation Protocol Using a Well-established Organelle Isolation Kit.Journal of visualized experiments : JoVE · 2019Article
- Inhibiting Ceramide Synthesis Attenuates Hepatic Steatosis and Fibrosis in Rats With Non-alcoholic Fatty Liver Disease.Frontiers in endocrinology · 2019Article
- Ethanol and C2 ceramide activate fatty acid oxidation in human hepatoma cells.Scientific reports · 2018Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Perilipin 2 (PLIN2) is a lipid-droplet protein that is up-regulated in alcoholic steatosis and associated with hepatic accumulation of ceramides, bioactive lipids implicated in alcoholic liver disease pathogenesis. The specific role of ceramide synthetic enzymes in the regulation of PLIN2 and promotion of hepatocellular lipid accumulation is not well understood. We examined the effects of pharmacologic ceramide synthesis inhibition on hepatic PLIN2 expression, steatosis, and glucose and lipid homeostasis in mice with alcoholic steatosis and in ethanol-incubated human hepatoma VL17A cells. In cells, pharmacologic inhibition of ceramide synthase reduced lipid accumulation by reducing PLIN2 RNA stability. The subtype ceramide synthase (CerS)6 was specifically up-regulated in experimental alcoholic steatosis
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