Evidence map›Paper›PMID 28864494›Full record

ArticleScience immunology2017

An immune clock of human pregnancy.

Nima Aghaeepour, Edward A Ganio, David Mcilwain, Amy S Tsai, Martha Tingle, Sofie Van Gassen, Dyani K Gaudilliere, Quentin Baca, Leslie McNeil, Robin Okada and 16 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 322 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
322citing papers in PubMed, 1 pooled it
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

322 citing papers in PubMed, 1 synthesis or guideline pooled it, 507 citations in OpenAlex.

  1. Burden of Dengue in Pregnant Individuals: A Systematic Literature Review.The American journal of tropical medicine and hygiene · 2026
    Pooled it
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  14. The HIV Reservoir and Immune Landscape Across the Life Course of Women: Implications for Cure Strategies.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
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262 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 4 institutions in 3 countries.

Nima AghaeepourDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.
Edward A GanioDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.ORCID http://orcid.org/0000-0002-1088-0377
David McilwainDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94121, USA.
Amy S TsaiDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.ORCID http://orcid.org/0000-0002-2380-6424
Martha TingleDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.ORCID http://orcid.org/0000-0003-4594-0584
Sofie Van GassenDepartment of Information Technology, Ghent University, and the Center for Inflammation Research, Ghent, Belgium.ORCID http://orcid.org/0000-0002-7119-5330
Dyani K GaudilliereDepartment of Surgery, Stanford University School of Medicine, Stanford, CA 94121, USA.ORCID http://orcid.org/0000-0003-3017-5939
Quentin BacaDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.
Leslie McNeilDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.ORCID http://orcid.org/0000-0003-2702-8751
Robin OkadaDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.ORCID http://orcid.org/0000-0002-4361-0146
Mohammad S GhaemiDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.
David FurmanInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ronald J WongDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94121, USA.
Virginia D WinnDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94121, USA.ORCID http://orcid.org/0000-0003-1136-2907
Maurice L DruzinDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94121, USA.ORCID http://orcid.org/0000-0001-7185-6664
Yaser Y El-SayedDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94121, USA.
Cecele QuaintanceDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94121, USA.ORCID http://orcid.org/0000-0002-9473-7243
Ronald GibbsDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94121, USA.ORCID http://orcid.org/0000-0002-0776-6602
Gary L DarmstadtDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94121, USA.
Gary M ShawDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94121, USA.
David K StevensonDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94121, USA.
Robert TibshiraniDepartments of Biomedical Data Sciences and Statistics, Stanford University, Stanford, CA 94121, USA.ORCID http://orcid.org/0000-0003-0553-5090
Garry P NolanDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94121, USA.
David B LewisDivision of Pediatric Immunology and Allergy, Stanford University School of Medicine, Stanford, CA 94121, USA.ORCID http://orcid.org/0000-0001-7181-0105
Martin S AngstDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.ORCID http://orcid.org/0000-0002-1550-8136
Brice GaudilliereDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA. gbrice@stanford.edu.ORCID http://orcid.org/0000-0002-3475-5706
Stanford Medicine · USStanford University · USHospital de Clínicas "José de San Martín" · ARVIB-UGent Center for Inflammation Research · BE

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Role of Myeloid Derived Suppressor Cells in the Immune Response to SurgeryK23GM111657 · NIGMS · STANFORD UNIVERSITY · PI GAUDILLIERE, BRICE · 2014 to 2017
$524k
NIAID NIH HHS U19 AI057229NIGMS NIH HHS K23 GM111657
6 · The paper itself

Abstract

The maintenance of pregnancy relies on finely tuned immune adaptations. We demonstrate that these adaptations are precisely timed, reflecting an immune clock of pregnancy in women delivering at term. Using mass cytometry, the abundance and functional responses of all major immune cell subsets were quantified in serial blood samples collected throughout pregnancy. Cell signaling-based Elastic Net, a regularized regression method adapted from the elastic net algorithm, was developed to infer and prospectively validate a predictive model of interrelated immune events that accurately captures the chronology of pregnancy. Model components highlighted existing knowledge and revealed previously unreported biology, including a critical role for the interleukin-2-dependent STAT5ab signaling pathway in modulating T cell function during pregnancy. These findings unravel the precise timing of immunological events occurring during a term pregnancy and provide the analytical framework to identify immunological deviations implicated in pregnancy-related pathologies.

Identifiers

PMID28864494
PMCPMC5701281
OpenAlexW2752229394

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.