Evidence map›Paper›PMID 28864420›Full record

ArticleBiochemical and biophysical research communications2017

Functional characterization of malaria parasites deficient in the K

Peter Ellekvist, Godfree Mlambo, Nirbhay Kumar, Dan A Klaerke

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Peter EllekvistMedical Department, Herlev & Gentofte Hospital, Copenhagen, Denmark. Electronic address: p.ellekvist@dadlnet.dk.
Godfree MlamboDepartment of Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Baltimore, MD, United States.
Nirbhay KumarDepartment of Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Baltimore, MD, United States; Department of Tropical Medicine, Tulane University School of Public Health & Tropical Medicine, New Orleans, LA, United States. Electronic address: nkumar@tulane.edu.
Dan A KlaerkeDepartment of Physiology and Biochemistry, IBHV, Faculty of Health & Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Johns Hopkins University · USGentofte Hospital · DKUniversity of Copenhagen · DK

Funding

MOLECULAR DISSECTION OF P. FALCIPARUM SEXUAL DEVELOPMENTR01AI046760 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KUMAR, NIRBHAY · 2000 to 2004
$1.8M
Malaria Training and Research Capacity Building in Southern AfricaD43TW001587 · FIC · TULANE UNIVERSITY OF LOUISIANA · PI KUMAR, NIRBHAY · 2000 to 2012
$1.4M
FIC NIH HHS D43 TW001587NIAID NIH HHS R01 AI046760
6 · The paper itself

Abstract

K

resultsGenetic disruption of Kch2 did not grossly affect the phenotype in terms of asexual replication and pathogenicity in a mouse model. In contrast to Kch1-null parasites, Kch2-null parasites were fully capable of forming oocysts in female Anopheles stephensi mosquitoes.

Indexed as

AnimalsAnophelesFemaleMalariaMaleMicePlasmodium bergheiPotassium ChannelsProtozoan ProteinsPotassium ChannelsProtozoan ProteinsGene knockoutK(+) channelsMalariaP. berghei

Identifiers

PMID28864420
PMCPMC5636674
OpenAlexW2753772525

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.