Evidence map›Paper›PMID 2886434›Full record

ArticleInfection and immunity1987

Stimulation by target cell membrane lipid of actin polymerization and phagocytosis by Entamoeba histolytica.

G B Bailey, D B Day, C Nokkaew, C C Harper

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Endocytosis in anaerobic parasitic protists.Memorias do Instituto Oswaldo Cruz · 2024
    Review
  2. Revisiting the Mechanisms of Immune Evasion Employed by Human Parasites.Frontiers in cellular and infection microbiology · 2021
    Review
  3. Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

G B Bailey
D B Day
C Nokkaew
C C Harper

Funding

THE ROLE OF ALKALINE PHOSPHATASE IN THE IMMUNE RESPONSES06RR008006 · NCRR · ATLANTA UNIVERSITY CENTER · PI JOHNSON, JOE · 1985 to 1989
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NCRR NIH HHS RR 08006NIAID NIH HHS AI 19023
6 · The paper itself

Abstract

The identity of molecules of mammalian target cells that stimulate contact-dependent attack by Entamoeba histolytica was sought using human erythrocytes (RBC) as a model. Protein-free liposomes prepared from RBC membrane lipids stimulated the same rapid E. histolytica actin polymerization and phagocytosis as did whole target cells. Liposomes constructed from the major phospholipids of RBC stimulated these responses but only if a negatively charged phospholipid was included. The addition to these liposomes of digalactosyl diglyceride significantly enhanced their stimulatory activity. The results demonstrate that ligands that trigger attack-related responses by E. histolytica reside in the target cell membrane lipid fraction and suggest roles for both glycolipid and phospholipid components.

Indexed as

PhagocytosisActin CytoskeletonActinsEndocytosisEntamoeba histolyticaErythrocytesGlycolipidsLiposomesMembrane LipidsPhospholipidsReceptors, Cell SurfaceActinsGlycolipidsLiposomesMembrane LipidsPhospholipidsReceptors, Cell Surface

Identifiers

PMID2886434
PMCPMC260612
OpenAlexW1897997059

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.