ArticleComparative biochemistry and physiology. Part B, Biochemistry & molecular biology2017
A START-domain-containing protein is a novel marker of nervous system components of the sea cucumber Holothuria glaberrima.
Article in Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Echinoderm Radial Glia-Like Cells Express Vertebrate Glial Markers.The Journal of comparative neurology · 2025Article
- Article
- Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium.bioRxiv : the preprint server for biology · 2024Article
- Intestine Explants in Organ Culture: A Tool to Broaden the Regenerative Studies in Echinoderms.Journal of marine science and engineering · 2022Article
- Dedifferentiation of radial glia-like cells is observed in in vitro explants of holothurian radial nerve cord.Journal of neuroscience methods · 2021Article
- The nervous system component of the mesentery of the sea cucumber Holothuria glaberrima in normal and regenerating animals.Cell and tissue research · 2020Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
One of the main challenges faced by investigators studying the nervous system of members of the phylum Echinodermata is the lack of markers to identify nerve cells and plexi. Previous studies have utilized an antibody, RN1, that labels most of the nervous system structures of the sea cucumber Holothuria glaberrima and other echinoderms. However, the antigen recognized by RN1 remained unknown. In the present work, the antigen has been characterized by immunoprecipitation, tandem mass spectrometry, and cDNA cloning. The RN1 antigen contains a START lipid-binding domain found in Steroidogenic Acute Regulatory (StAR) proteins and other lipid-binding proteins. Phylogenetic tree assembly showed that the START domain is highly conserved among echinoderms. We have named this antigen HgSTARD10 for its high sequence similarity to the vertebrate orthologs. Gene and protein expression analyses revealed an abundance of HgSTARD10 in most H. glaberrima tissues including radial nerve, intestine, muscle, esophagus, mesentery, hemal system, gonads and respiratory tree. Molecular cloning of HgSTARD10, consequent protein expression and polyclonal antibody production revealed the STARD10 ortholog as the antigen recognized by the RN1 antibody. Further characterization into this START domain-containing protein will provide important insights for the biochemistry, physiology and evolution of deuterostomes.
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