ArticleJournal of ethnopharmacology2018
Artemisinin permeability via Caco-2 cells increases after simulated digestion of Artemisia annua leaves.
Article in Journal of ethnopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Uptake and Transport of Monotropein and Monotropein Esters in a Caco-2/HT29-MTX-E12 Co-Culture Model.Molecular nutrition & food research · 2026Article
- Enterocyte Culture on a Hybrid Transwell-Inserted Gut-on-a-Chip for Liquid-Liquid and Air-Liquid Interface Conditions.ACS omega · 2025Article
- Medicinal plants as more sustainable therapeutic solutions:Global health economics and sustainability · 2025Article
- The plant matrix of Artemisia annua L. for the treatment of malaria: Pharmacodynamic and pharmacokinetic studies.PloS one · 2025Article
- Multi-omics unveils strain-specific neuroactive metabolite production linked to inflammation modulation byCurrent research in microbial sciences · 2025Article
- Differential Anti-Fibrotic and Remodeling Responses of Human Dermal Fibroblasts toMolecules (Basel, Switzerland) · 2024Article
- Enhancing Oral Bioavailability of Domperidone Maleate: Formulation,Current drug delivery · 2024Article
- Artemisinin as a therapeuticNatural product reports · 2023Review
- Artemisia extracts differ from artemisinin effects on human hepatic CYP450s 2B6 and 3A4 in vitro.Journal of ethnopharmacology · 2022Article
- Specialty molecules from plants and in vitro cultures as new drugs: regulatory considerations from flask to patient.Plant cell, tissue and organ culture · 2022Article
- Transcriptional regulation of flavonoid biosynthesis in Artemisia annua by AaYABBY5.Horticulture research · 2021Article
- An overview of the anti-SARS-CoV-2 properties of Artemisia annua, its antiviral action, protein-associated mechanisms, and repurposing for COVID-19 treatment.Journal of integrative medicine · 2021Review
- Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants.Journal of ethnopharmacology · 2021Article
- Article
- Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics.Acta pharmaceutica Sinica. B · 2021Review
- In vitro analyses of Artemisia extracts on Plasmodium falciparum suggest a complex antimalarial effect.PloS one · 2021Article
- Dried LeafBiomolecules · 2020Article
- It is not just artemisinin:Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2019Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
ethnopharmacological relevanceArtemisia annua has been used for > 2000yrs to treat fever and is more recently known for producing the important antimalarial drug, artemisinin. AIM OF THE STUDY: Artemisinin combination therapies (ACTs) are effective for treating malaria, but are often unavailable to those in need. Dried leaves of A. annua (DLA) have recently been studied as a cost effective alternative to traditional ACTs. DLA was shown to dramatically increase oral bioavailability compared to pure artemisinin, so more investigation into the mechanisms causing this increased bioavailability is needed. MATERIALS AND
methodsIn this study, we used a simulated digestion system coupled with Caco-2 cell permeability assays to investigate the intestinal permeability of DLA compared to pure artemisinin. We also determined the effects of different phytochemicals (7 flavonoids, 3 monoterpenes, 2 phenolic acids, scopoletin and inulin) and the cytochrome P450 isoform CYP3A4 on artemisinin intestinal permeability.
resultsArtemisinin permeability, when delivered as digested DLA, significantly increased by 37% (P
conclusionsThese results shed light on the mechanisms by which DLA enhances the oral bioavailability of artemisinin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.