Evidence map›Paper›PMID 28864149›Full record

ArticleBioorganic & medicinal chemistry2017

Anticancer potential of aminomethylidene-diazinanes I. Synthesis of arylaminomethylidene of diazinetriones and its cytotoxic effects tested in glioblastoma cells.

Nichole A Pianovich, Mathew Dean, Adam Lassak, Krzysztof Reiss, Branko S Jursic

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nichole A PianovichDepartment of Chemistry, University of New Orleans, New Orleans, LA 70148, USA.
Mathew DeanNeurological Cancer Research, Stanley S. Scott Cancer Center, Department of Medicine, LSU Health Sciences Center, New Orleans, LA 70119 USA.
Adam LassakNeurological Cancer Research, Stanley S. Scott Cancer Center, Department of Medicine, LSU Health Sciences Center, New Orleans, LA 70119 USA.
Krzysztof ReissNeurological Cancer Research, Stanley S. Scott Cancer Center, Department of Medicine, LSU Health Sciences Center, New Orleans, LA 70119 USA.
Branko S JursicDepartment of Chemistry, University of New Orleans, New Orleans, LA 70148, USA; STEPHARM, LLC., PO Box 24220, New Orleans, LA 70184, USA. Electronic address: bjursic1@uno.edu.

Funding

Translational Genomics Core (TGC)P20GM121288 · NIGMS · LSU HEALTH SCIENCES CENTER · PI For Yue Tso · 2017 to 2026
$22.4M
Mentoring Translational Researchers in LouisianaP20GM103501 · NIGMS · LSU HEALTH SCIENCES CENTER · PI OCHOA, AUGUSTO C. · 2012 to 2014
$6.3M
NIGMS NIH HHS P20 GM103501NIGMS NIH HHS P20 GM121288
6 · The paper itself

Abstract

Diazinane and aryl moieties with vinylamine linkers were synthesized to investigate the importance of their structural variations as potential anti-glioblastoma agents. Structural variations incorporated on to the diazinane moiety included oxa and thio derivatives, each with a variety of nitrogen-bound substituents. The size and shape of the aromatic moiety was varied, with the final variation introducing two carbonyl groups, yielding a substituted anthraquinone. Readily available diazinanes and aryl amines were used asan advantageous foundation. Several parameters were calculated whilst engineering these compounds, including: ClogP, molecular polarizability, polar surface area, minimal molecular projected area, and pK

Indexed as

AminationAnthraquinonesAntineoplastic AgentsBarbituratesCell DeathCell Line, TumorDrug Screening Assays, AntitumorGlioblastomaHumans5-(((9,10-dioxo-9,10-dihydroanthracen-1-yl)amino)methylidene)-1,3-diazinane-2,4,6-trioneAnthraquinonesAntineoplastic AgentsBarbituratesAnticancerCarbamoylDiazinaneGlioblastomaMerbarone

Identifiers

PMID28864149
PMCPMC5870872

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.