Observational studyFertility and sterility2017
Semen quality and pregnancy loss in a contemporary cohort of couples recruited before conception: data from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study.
Observational study in Fertility and sterility, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Relationship Among Traditional Semen Parameters, Sperm DNA Fragmentation, and Unexplained Recurrent Miscarriage: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Longitudinal semen parameter assessments and live birth: variability and implications for treatment strategies.Fertility and sterility · 2022Trial
- A prospective study of periconceptional perceived stress and rate of miscarriage.Human reproduction (Oxford, England) · 2026Article
- Association of sperm DNA fragmentation with higher miscarriage rates in non-male factor infertility reproductive cycles.Translational andrology and urology · 2025Article
- Burden, causes, and treatment approaches of recurrent pregnancy loss: a scoping review.The Pan African medical journal · 2025Article
- Male Contributory Factors in Recurrent Pregnancy Loss.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Sexual dysfunction is more common among men who have high sperm DNA fragmentation or teratozoopermia.Scientific reports · 2022Article
- Repair mechanism of Wuwei Fuzheng Yijing formula in di-2-ethylhexyl phthalate-induced sperm DNA fragmentation in mice.Pharmaceutical biology · 2022Article
- Subfertile patients underestimate their risk factors of reprotoxic exposure.Basic and clinical andrology · 2022Article
- Male factor testing in recurrent pregnancy loss cases: A narrative review.International journal of reproductive biomedicine · 2022Review
- A Prospective Cohort Study of Seasonal Variation in Spontaneous Abortion.Epidemiology (Cambridge, Mass.) · 2022Article
- Sperm selection during ICSI treatments reduces single- but not double-strand DNA break values compared to the semen sample.Journal of assisted reproduction and genetics · 2021Article
- Male Preconception Marijuana Use and Spontaneous Abortion: A Prospective Cohort Study.Epidemiology (Cambridge, Mass.) · 2021Article
- Sperm DNA Fragmentation: A New Guideline for Clinicians.The world journal of men's health · 2020Review
- Tracking research trends and hotspots in sperm DNA fragmentation testing for the evaluation of male infertility: a scientometric analysis.Reproductive biology and endocrinology : RB&E · 2019Review
- Effect of varicocele repair on sperm DNA fragmentation: a review.International urology and nephrology · 2018Review
- Sperm morphology: Evaluating its clinical relevance in contemporary fertility practice.Reproductive medicine and biologyReview
Corrections and comments
- Commented on by
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo study the relationship between semen quality and pregnancy loss in a cohort of couples attempting to conceive.
designObservational prospective cohort.
settingNot applicable. PATIENT(S): Three hundred and forty-four couples with a singleton pregnancy observed daily through 7 postconception weeks of gestation. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Association between semen quality and pregnancy loss. RESULT(S): Ninety-eight (28%) of the couples experienced a pregnancy loss after singleton pregnancy. No differences were observed in semen volume, sperm concentration, total sperm count, sperm viability, or sperm morphology (World Health Organization [WHO] and strict criteria) by couple's pregnancy loss status irrespective of whether they were analyzed continuously or as dichotomous variables per the WHO 5th edition semen criteria. A dichotomous DNA fragmentation measure of ≥30% was statistically significantly associated with pregnancy loss. No association was identified with other sperm morphometric or movement measures. Of the 70 couples who re-enrolled after a pregnancy loss, 14 experienced a second loss. Similar findings were identified when examining semen quality from couples with recurrent pregnancy loss. CONCLUSION(S): Although a few trends were identified (e.g., DNA fragmentation), general semen parameters seemed to have little relation with risk of pregnancy loss or recurrent pregnancy loss at the population level. However, given that 30% of pregnancies end in miscarriage and half the fetal genome is paternal in origin, the findings await corroboration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.