ArticleThe Journal of chemical physics2017
Effect of stochastic gating on channel-facilitated transport of non-interacting and strongly repelling solutes.
Article in The Journal of chemical physics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Effect of stochastic gating on the flux through a membrane channel: a steady-state approach.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Article
- Stochastic Gating as a Novel Mechanism for Channel Selectivity.Biophysical journal · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Ligand- or voltage-driven stochastic gating-the structural rearrangements by which the channel switches between its open and closed states-is a fundamental property of biological membrane channels. Gating underlies the channel's ability to respond to different stimuli and, therefore, to be functionally regulated by the changing environment. The accepted understanding of the gating effect on the solute flux through the channel is that the mean flux is the product of the flux through the open channel and the probability of finding the channel in the open state. Here, using a diffusion model of channel-facilitated transport, we show that this is true only when the gating is much slower than the dynamics of solute translocation through the channel. If this condition breaks, the mean flux could differ from this simple estimate by orders of magnitude.
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Registered trials
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