ArticleDevelopmental cognitive neuroscience2017
Cognitive flexibility and its electrophysiological correlates in Gilles de la Tourette syndrome.
Article in Developmental cognitive neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Altered dynamic functional and effective connectivity in drug-naive children with Tourette syndrome.Translational psychiatry · 2024Article
- P3b Amplitude and Latency in Tic Disorders: A Meta-Analysis.Brain sciences · 2022Review
- Altered medial prefrontal cortex and dorsal raphé activity predict genotype and correlate with abnormal learning behavior in a mouse model of autism-associated 2p16.3 deletion.Autism research : official journal of the International Society for Autism Research · 2022Article
- Capturing Subtle Neurocognitive Differences in Children with and without Tourette Syndrome through a Fine-Grained Analysis of Design Fluency Profiles.Journal of clinical medicine · 2022Article
- European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part I: assessment.European child & adolescent psychiatry · 2022Review
- The Wisconsin Card Sorting Test: Split-Half Reliability Estimates for a Self-Administered Computerized Variant.Brain sciences · 2021Article
- Review
- Toward a Computational Neuropsychology of Cognitive Flexibility.Brain sciences · 2020Review
- Autism spectrum heterogeneity: fact or artifact?Molecular psychiatry · 2020Review
- Parallel model-based and model-free reinforcement learning for card sorting performance.Scientific reports · 2020Article
- A Computational Study of Executive Dysfunction in Amyotrophic Lateral Sclerosis.Journal of clinical medicine · 2020Article
- Computational Modeling for Neuropsychological Assessment of Bradyphrenia in Parkinson's Disease.Journal of clinical medicine · 2020Article
- Impairment of visually guided associative learning in children with Tourette syndrome.PloS one · 2020Article
- A Meta-Analysis of Relationships between Measures of Wisconsin Card Sorting and Intelligence.Brain sciences · 2019Review
- Trichotillomania is more related to Tourette disorder than to obsessive-compulsive disorder.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Review
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor symptoms in Gilles de la Tourette syndrome (GTS) have been related to changes in frontostriatal brain networks. These changes may also give rise to alterations in cognitive flexibility. However, conclusive evidence for altered cognitive flexibility in patients with GTS is still lacking. Here, we meta-analyzed data from 20 neuropsychological studies that investigated cognitive flexibility in GTS using the Wisconsin Card Sorting Test (WCST). Results revealed medium-sized GTS-related performance deficits, which were significantly modulated by age: Whilst being substantial in children and adolescents with GTS, WCST deficits seem to dissolve in adult patients with GTS. This age-related normalization of WCST performance might result from the compensatory recruitment of cognitive control in adult patients with GTS. We addressed this possibility by examining neural correlates of proactive and reactive cognitive control in an event-related potential (ERP) study. We analyzed cue- and target-locked ERPs from 23 adult patients with GTS and 26 matched controls who completed a computerized version of the WCST. Compared to controls, patients with GTS showed a marked increase in parietal cue-locked P3 activity, indicating enhanced proactive cognitive control. We conclude that the additional recruitment of proactive cognitive control might ensure flexible cognitive functioning in adult patients with GTS.
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