Evidence map›Paper›PMID 28863316›Full record

Trial reportAddictive behaviors2018

Use of hormonal contraceptives and smoking cessation: A preliminary report.

Alicia M Allen, Samantha Carlson, Lynn E Eberly, Dorothy Hatsukami, Megan E Piper

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Addictive behaviors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Oral Contraceptives and Cigarette Smoking: A Review of the Literature and Future Directions.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Alicia M AllenDepartment of Family & Community Medicine, College of Medicine, University of Arizona, 3950 South Country Club Drive, Suite 330, Tucson, AZ 85742, United States. Electronic address: aliciaallen@email.arizona.edu.
Samantha CarlsonDepartment of Family Medicine & Community Health, Medical School, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN 55414, United States.
Lynn E EberlyDivision of Biostatistics, School of Public Health, University of Minnesota, 420 Delaware Street SE, MMC 303 Mayo, Minneapolis, MN 55455, United States.
Dorothy HatsukamiDepartment of Psychiatry, Medical School, University of Minnesota, 717 Delaware Street SE, Room 260, Minneapolis, MN 55414, United States.
Megan E PiperDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, 1930 Monroe Street, Suite 200, Madison, WI 53711, United States.
University of Minnesota · USUniversity of Arizona · USUniversity of Wisconsin–Madison · US

Funding

Enhancing the Effectiveness of Varenicline Based Smoking Cessation TreatmentR01HL109031 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BAKER, TIMOTHY B, STEIN, JAMES H · 2011 to 2020
$17.5M
Tobacco Dependence: Treatment and OutcomesP50DA019706 · NIDA · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON-POWELL, GLORIA · 2004 to 2008
$8.6M
Univ of Minnesota Buidling Interdisciplinary Research Careers in Women's HealthK12HD055887 · NICHD · UNIVERSITY OF MINNESOTA · PI ALLEN, SHARON S, BERGE, JERICA M · 2007 to 2023
$8.6M
NHLBI NIH HHS R01 HL109031NICHD NIH HHS K12 HD055887NIDA NIH HHS P50 DA019706
6 · The paper itself

Abstract

Although endogenous sex hormones influence smoking-related outcomes, little is known about the effect of exogenous sex hormones. Therefore, the goal of this preliminary study was to examine differences in withdrawal symptoms and cessation between women using hormonal contraceptives (HC), women not using hormonal contraceptives (no-HC) and men. Utilizing data from two recently completed smoking cessation randomized clinical trials, we selected participants who were between the ages of 18-35years old. Participants were classified based on use of hormonal contraceptives and gender, then matched based on pharmacotherapy randomization assignment and baseline cigarettes per day. Participants provided self-reported assessments on withdrawal, craving and negative affect, and smoking status was assessed for 52weeks after quit date. Participants (N=130) were 28.7±0.4years old and smoked 16.8±0.6 cigarettes/day. Compared to both no-HC and men, the HC group had significantly greater withdrawal one week prior to the quit date, on the quit date and one week after the quit date. During the first week of attempted abstinence, craving declined in HC and in men, but increased in no-HC. At end of treatment, the HC group was at 3.73 times higher odds of being abstinent compared to men (95% confidence interval: 1.12-12.40). There were no group differences in abstinence rates at Week 26 or 52. These data suggest that HC users may experience more adverse levels of withdrawal, though may be more likely to achieve short-term abstinence. Future research is needed to replicate our observations and explore mechanisms of action.

Indexed as

AdultCigarette SmokingContraceptive AgentsCravingEstrogensFemaleHumansMaleSex FactorsSmoking CessationSubstance Withdrawal SyndromeContraceptive AgentsEstrogensCessationCravingGender/sex differencesHormonesWithdrawalWomen

Identifiers

PMID28863316
PMCPMC5614855
OpenAlexW2743652309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.