Evidence map›Paper›PMID 28863246›Full record

ArticleBiometrics2018

FLCRM: Functional linear cox regression model.

Dehan Kong, Joseph G Ibrahim, Eunjee Lee, Hongtu Zhu

Abstract read
In one paragraph

Article in Biometrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Semiparametric Joint Modeling for Survival Analysis with Longitudinal Covariates.Journal of the American Statistical Association · 2026
    Article
  5. Functional varying-coefficient Cox model and its application.Statistical methods in medical research · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Recurrent event analysis in the presence of real-time high frequency data via random subsampling.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Shape Analysis of Functional Data With Elastic Partial Matching.IEEE transactions on pattern analysis and machine intelligence · 2022
    Article
  17. Article
  18. Article
  19. Additive Functional Cox Model.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dehan KongDepartment of Statistical Sciences, University of Toronto, Ontario, Canada.
Joseph G IbrahimDepartment of Biostatistics, University of North Carolina at Chapel Hill, North Carolina, U.S.A.
Eunjee LeeDepartment of Biostatistics, University of Michigan, Michigan, U.S.A.
Hongtu ZhuDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Texas, U.S.A.ORCID 0000-0002-6781-2690

Funding

Statistical Methods for Cancer Clinical TrialsP01CA142538 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KOSOROK, MICHAEL R · 2010 to 2019
$21.3M
Bayesian Approaches to Model Selection for Survival DataR01GM070335 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IBRAHIM, JOSEPH G · 2003 to 2019
$4.0M
Statistical Analysis of Biomedical Imaging Data in Curved SpaceR01MH086633 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IBRAHIM, JOSEPH G · 2010 to 2018
$2.9M
Genome-wide Identification of Variants Affecting Early Human Brain DevelopmentR01MH092335 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KNICKMEYER, REBECCA · 2011 to 2015
$2.5M
Longitudinal Analysis of Biomedical Imaging DataR21AG033387 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZHU, HONGTU · 2009 to 2010
$334k
NCI NIH HHS P01 CA142538NIA NIH HHS R21 AG033387NIGMS NIH HHS R01 GM070335NIMH NIH HHS R01 MH086633NIMH NIH HHS R01 MH092335
6 · The paper itself

Abstract

We consider a functional linear Cox regression model for characterizing the association between time-to-event data and a set of functional and scalar predictors. The functional linear Cox regression model incorporates a functional principal component analysis for modeling the functional predictors and a high-dimensional Cox regression model to characterize the joint effects of both functional and scalar predictors on the time-to-event data. We develop an algorithm to calculate the maximum approximate partial likelihood estimates of unknown finite and infinite dimensional parameters. We also systematically investigate the rate of convergence of the maximum approximate partial likelihood estimates and a score test statistic for testing the nullity of the slope function associated with the functional predictors. We demonstrate our estimation and testing procedures by using simulations and the analysis of the Alzheimer's Disease Neuroimaging Initiative (ADNI) data. Our real data analyses show that high-dimensional hippocampus surface data may be an important marker for predicting time to conversion to Alzheimer's disease. Data used in the preparation of this article were obtained from the ADNI database (adni.loni.usc.edu).

Indexed as

Linear ModelsProportional Hazards ModelsAlzheimer DiseaseHippocampusHumansLikelihood FunctionsModels, StatisticalNeuroimagingPrincipal Component AnalysisTime FactorsCox regressionFunctional predictorFunctional principal component analysisScore test

Identifiers

PMID28863246
PMCPMC5832538

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.