Evidence map›Paper›PMID 28862946›Full record

ArticleJournal of the American Heart Association2017

α

Lauren J Albee, Jonathan M Eby, Abhishek Tripathi, Heather M LaPorte, Xianlong Gao, Brian F Volkman, Vadim Gaponenko, Matthias Majetschak

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. αPharmacological research · 2023
    Article
  5. αInternational journal of molecular sciences · 2023
    Review
  6. Heteromerization between αFEBS letters · 2022
    Article
  7. αProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Article
  9. Article
  10. Chemokine receptor antagonists with αJournal of basic and clinical physiology and pharmacology · 2021
    Article
  11. Cardiac α1A-adrenergic receptors: emerging protective roles in cardiovascular diseases.American journal of physiology. Heart and circulatory physiology · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lauren J AlbeeDepartment of Surgery, Burn and Shock Trauma Research Institute, Loyola University Chicago Stritch School of Medicine, Maywood, IL.
Jonathan M EbyDepartment of Surgery, Burn and Shock Trauma Research Institute, Loyola University Chicago Stritch School of Medicine, Maywood, IL.
Abhishek TripathiDepartment of Surgery, Burn and Shock Trauma Research Institute, Loyola University Chicago Stritch School of Medicine, Maywood, IL.
Heather M LaPorteDepartment of Surgery, Burn and Shock Trauma Research Institute, Loyola University Chicago Stritch School of Medicine, Maywood, IL.
Xianlong GaoDepartment of Surgery, Burn and Shock Trauma Research Institute, Loyola University Chicago Stritch School of Medicine, Maywood, IL.
Brian F VolkmanDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI.
Vadim GaponenkoDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, IL.
Matthias MajetschakDepartment of Surgery, Burn and Shock Trauma Research Institute, Loyola University Chicago Stritch School of Medicine, Maywood, IL mmajetschak@luc.edu.
Loyola University Chicago · USMedical College of Wisconsin · USUniversity of Illinois Chicago · US

Funding

Structural Basis for Chemokine FunctionR01AI058072 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI VOLKMAN, BRIAN F · 2004 to 2019
$4.1M
Structural Basis for Chemokine FunctionR37AI058072 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Brian F Volkman · 2020 to 2026
$2.8M
Regulation of tyrosine kinase signaling through interaction with membrane lipidsR01CA188427 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GAPONENKO, VADIM V, TYNER, ANGELA L · 2015 to 2019
$2.1M
Chemokine control of cardiovascular function during hemorrhagic shockR01GM107495 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI MAJETSCHAK, MATTHIAS · 2014 to 2017
$1.1M
NCI NIH HHS R01 CA188427NIAID NIH HHS R01 AI058072NIAID NIH HHS R37 AI058072NIGMS NIH HHS R01 GM107495
6 · The paper itself

Abstract

backgroundRecently, we provided evidence that α METHODS AND

resultsWe show that ACKR3 agonists inhibit inositol trisphosphate production in hVSMCs on stimulation with phenylephrine. In proximity ligation assays and co-immunoprecipitation experiments, we observed that recombinant and endogenous ACKR3 form heteromeric complexes with α

conclusionsα

Indexed as

Receptor Cross-TalkAdenosine TriphosphateAdrenergic alpha-1 Receptor AgonistsDose-Response Relationship, DrugHEK293 CellsHumansLigandsMultiprotein ComplexesMuscle, Smooth, VascularMyocytes, Smooth MuscleProtein BindingProtein Interaction Domains and MotifsReceptors, Adrenergic, alpha-1Receptors, CXCRReceptors, CXCR4RNA InterferenceACKR3 protein, humanAdenosine TriphosphateADRA1A protein, humanADRA1B protein, humanADRA1D protein, humanAdrenergic alpha-1 Receptor AgonistsCXCR4 protein, humanLigandsMultiprotein ComplexesReceptors, Adrenergic, alpha-1Receptors, CXCRReceptors, CXCR4adrenergic receptoralphablood pressurechemokineC‐X‐C motif chemokine ligand 11C‐X‐C motif chemokine ligand 12phenylephrinevasoconstriction

Identifiers

PMID28862946
PMCPMC5586474
OpenAlexW2750156093

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.