ArticlePsychophysiology2018
Testing a linear time invariant model for skin conductance responses by intraneural recording and stimulation.
Article in Psychophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Effects of doxycycline on intrusive experimental trauma memory: a pre-registered, randomized double-blind placebo-controlled trial.Translational psychiatry · 2026Trial
- The impact of doxycycline on human contextual fear memory.Psychopharmacology · 2024Trial
- Clinical use of electrodermal activity and current developments.European biophysics journal : EBJ · 2026Review
- Measuring Human Pavlovian Reward Conditioning and Memory Retention After Consolidation.Psychophysiology · 2025Article
- Dimensionality and optimal combination of autonomic fear-conditioning measures in humans.Behavior research methods · 2024Article
- Threat and Reward Imminence Processing in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Aerobic exercise after extinction learning reduces return of fear and enhances memory of items encoded during extinction learning.Mental health and physical activity · 2023Article
- Filtering and model-based analysis independently improve skin-conductance response measures in the fMRI environment: Validation in a sample of women with PTSD.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020Article
- Anxiety and the Neurobiology of Temporally Uncertain Threat Anticipation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Impact of a reminder/extinction procedure on threat-conditioned pupil size and skin conductance responses.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Psychophysiological modelling and the measurement of fear conditioning.Behaviour research and therapy · 2020Review
- Threat Memory Reminder Under Matrix Metalloproteinase 9 Inhibitor Doxycycline Globally Reduces Subsequent Memory Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Pavlovian-to-instrumental transfer after human threat conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Human Pavlovian fear conditioning conforms to probabilistic learning.PLoS computational biology · 2018Article
- Testing a linear time invariant model for skin conductance responses by intraneural recording and stimulation.Psychophysiology · 2018Article
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4 authors.
Funding
Abstract
Skin conductance responses (SCR) are increasingly analyzed with model-based approaches that assume a linear and time-invariant (LTI) mapping from sudomotor nerve (SN) activity to observed SCR. These LTI assumptions have previously been validated indirectly, by quantifying how much variance in SCR elicited by sensory stimulation is explained under an LTI model. This approach, however, collapses sources of variability in the nervous and effector organ systems. Here, we directly focus on the SN/SCR mapping by harnessing two invasive methods. In an intraneural recording experiment, we simultaneously track SN activity and SCR. This allows assessing the SN/SCR relationship but possibly suffers from interfering activity of non-SN sympathetic fibers. In an intraneural stimulation experiment under regional anesthesia, such influences are removed. In this stimulation experiment, about 95% of SCR variance is explained under LTI assumptions when stimulation frequency is below 0.6 Hz. At higher frequencies, nonlinearities occur. In the intraneural recording experiment, explained SCR variance is lower, possibly indicating interference from non-SN fibers, but higher than in our previous indirect tests. We conclude that LTI systems may not only be a useful approximation but in fact a rather accurate description of biophysical reality in the SN/SCR system, under conditions of low baseline activity and sporadic external stimuli. Intraneural stimulation under regional anesthesia is the most sensitive method to address this question.
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