ArticleActa obstetricia et gynecologica Scandinavica2017
Doppler-based fetal heart rate analysis markers for the detection of early intrauterine growth restriction.
Article in Acta obstetricia et gynecologica Scandinavica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review on the utility of non-invasive electrophysiological assessment in evaluating for intra uterine growth restriction.BMC pregnancy and childbirth · 2019Pooled it
- Next-Generation Fetal Heart Monitoring: Leveraging Neural Sequential Modeling for Ultrasound Analysis.IEEE transactions on bio-medical engineering · 2026Article
- Optimizing Fetal Surveillance in Fetal Growth Restriction: A Narrative Review of the Role of the Computerized Cardiotocographic Assessment.Journal of clinical medicine · 2025Review
- Fetal heart rate spectral analysis in raw signals and PRSA-derived curve: normal and pathological fetuses discrimination.Medical & biological engineering & computing · 2024Article
- Hierarchical Attentive Network for Gestational Age Estimation in Low-Resource Settings.IEEE journal of biomedical and health informatics · 2023Article
- Fetal growth restriction and stillbirth: Biomarkers for identifying at risk fetuses.Frontiers in physiology · 2022Review
- A review of fetal cardiac monitoring, with a focus on low- and middle-income countries.Physiological measurement · 2020Review
- Comparison of Multivariable Logistic Regression and Other Machine Learning Algorithms for Prognostic Prediction Studies in Pregnancy Care: Systematic Review and Meta-Analysis.JMIR medical informatics · 2020Review
- Glucose Variability as Measured by Inter-measurement Percentage Change is Predictive of In-patient Mortality in Aneurysmal Subarachnoid Hemorrhage.Neurocritical care · 2020Article
- Unsupervised hidden semi-Markov model for automatic beat onset detection in 1D Doppler ultrasound.Physiological measurement · 2020Article
- A Proxy for Detecting IUGR Based on Gestational Age Estimation in a Guatemalan Rural Population.Frontiers in artificial intelligence · 2020Article
- Cardiotocography and beyond: a review of one-dimensional Doppler ultrasound application in fetal monitoring.Physiological measurement · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
introductionOne indicator for fetal risk of mortality is intrauterine growth restriction (IUGR). Whether markers reflecting the impact of growth restriction on the cardiovascular system, computed from a Doppler-derived heart rate signal, would be suitable for its detection antenatally was studied. MATERIAL AND
methodsWe used a cardiotocography archive of 1163 IUGR cases and 1163 healthy controls, matched for gestation and gender. We assessed the discriminative power of short-term variability and long-term variability of the fetal heart rate, computed over episodes of high and low variation aiming to separate growth-restricted fetuses from controls. Metrics characterizing the sleep state distribution within a trace were also considered for inclusion into an IUGR detection model.
resultsSignificant differences in the risk markers comparing growth-restricted with healthy fetuses were found. When used in a logistic regression classifier, their performance for identifying IUGR was considerably superior before 34 weeks of gestation. Long-term variability in active sleep was superior to short-term variability [area under the receiver operator curve (AUC) of 72% compared with 71%]. Most predictive was the number of minutes in high variation per hour (AUC of 75%). A multivariate IUGR prediction model improved the AUC to 76%.
conclusionWe suggest that heart rate variability markers together with surrogate information on sleep states can contribute to the detection of early-onset IUGR.
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