Evidence map›Paper›PMID 28862668›Full record

ArticleMolecules (Basel, Switzerland)2017

Origin and Formation Mechanism Investigation of Compound Precipitation from the Traditional Chinese Prescription Huang-Lian-Jie-Du-Tang by Isothermal Titration Calorimetry.

Hui Wang, Tong Li, Hongjun Xiang, Xinyu Zhang, Kang Fang, Gaorong Wu, Mengmeng Yan, Nannan Xue, Meng Chen, Tianxin Xie and 3 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hui WangSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. 15652387323@163.com.
Tong LiSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. lt1755258545@163.com.
Hongjun XiangSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. iloveygr@163.com.
Xinyu ZhangSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. xinyums@126.com.
Kang FangSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. 18361466994@163.com.
Gaorong WuSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. gaorongwu@163.com.
Mengmeng YanSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. yanmengmeng@bucm.edu.cn.
Nannan XueSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. 18810612758@163.com.
Meng ChenSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. 18702267252@163.com.
Tianxin XieSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. xietx1993@163.com.
Yuzhong ZhangDepartment of Pathology, Beijing University of Chinese Medicine, Beijing 100102, China. zyz100102@126.com.
Penglong WangSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. wpl581@126.com.
Haimin LeiSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. hm_lei@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have shown that compounds in the form of precipitate (CFP) from Huang-Lian-Jie-Du-Tang (HLJDT) were stable, and the CFP content reached 2.63% of the whole decoction and had good neuroprotective effects. However, there has been no research on their specific source. In this study, it was found that HLJDT CFP mainly came from the reaction of Scutellaria baicalensis and Coptis chinensis by studying the separated prescription components (accounting for 81.33% of HLJDT CFP). Unlike previous studies on HLJDT CFP, in this research the chemical composition of Scutellaria baicalensis-Coptis chinensis (SB-CC) CFP was identified by high performance liquid chromatography coupled with mass spectrometry (HPLC-MS

Indexed as

Chemical PrecipitationMedicine, Chinese TraditionalAnimalsBerberineCalorimetryCell ShapeChromatography, High Pressure LiquidDrugs, Chinese HerbalFlavonoidsMass SpectrometryNeuroprotective AgentsPC12 CellsPrescription DrugsRatsScutellaria baicalensisThermodynamicsbaicalinBerberineDrugs, Chinese HerbalFlavonoidshuang-lien-chieh-tu-tangNeuroprotective AgentsPrescription Drugscompounds in the form of precipitation (CFP)Huang-Lian-Jie-Du-Tang (HLJDT)isothermal titration calorimetry (ITC)neuroprotective effectseparated prescriptions

Identifiers

PMID28862668
PMCPMC6151706

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.