ReviewChildren (Basel, Switzerland)2017
Fever in Children: Pearls and Pitfalls.
Review in Children (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Effectiveness and safety of interventions for fever-associated discomfort in children: A systematic review.British journal of clinical pharmacology · 2025Pooled it
- Association between point mutations of macrolide-resistantFrontiers in pharmacology · 2025Pooled it
- Definition and assessment of fever-related discomfort in pediatric literature: a systematic review.European journal of pediatrics · 2024Pooled it
- Antipyretic effect of oral dipyrone (Metamizole) compared to oral ibuprofen in febrile children: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Trial
- Defining fever-related discomfort in children: an international Delphi consensus.European journal of pediatrics · 2026Article
- Diurnal variations of fever in children: results from an app-based observational study.BMC pediatrics · 2026Observational
- Prevalence and factors associated with acute kidney injury in children presenting to the emergency department with a first tonic-clonic seizure: an exploratory study.European journal of pediatrics · 2026Article
- Evaluation of Parental Knowledge and Practices in Pediatric Fever Management Among Iranian Families: A Cross-Sectional Study.Pediatric reports · 2026Article
- Individual and Combined Associations of Maternal Fever, Placental Inflammation, and Prematurity With Autism and ADHD.Journal of autism and developmental disorders · 2026Article
- A primary healthcare approach to children with fever.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2026Article
- TRPV1 mediates mitochondrial dysfunction in hyperthermia-induced ameloblast mineralization defects.Frontiers in cell and developmental biology · 2026Article
- Efficacy and Safety of Paracetamol and NSAIDs for Fever and Pain Management in Children with Chronic Diseases: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Optimizing fever management in pediatric emergency medicine: pathophysiology, diagnostics, and evidence-based strategies.International journal of emergency medicine · 2025Review
- Management of Infants Treated for Respiratory Viral Infections: A Finnish Retrospective Register-Based Study.Health science reports · 2025Article
- Association of fever and infections with the subsequent risk of atopic diseases in children with genetic susceptibility for T1D: Results from the TEDDY cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- When infection hurts: golden rules for managing pediatric skin and soft tissue infections.Italian journal of pediatrics · 2025Review
- Many Roads to Irritability: How Developmental Change and Multiple Risk Pathways Can Impact Negative Findings in Resting-State Connectivity.Biological psychiatry global open science · 2025Article
- Fever assessment in children under five: Are we following the guidelines?World journal of clinical pediatrics · 2024Article
- Recurrent upper respiratory tract infections in early childhood: a newly defined clinical condition.Italian journal of pediatrics · 2024Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fever in children is a common concern for parents and one of the most frequent presenting complaints in emergency department visits, often involving non-pediatric emergency physicians. Although the incidence of serious infections has decreased after the introduction of conjugate vaccines, fever remains a major cause of laboratory investigation and hospital admissions. Furthermore, antipyretics are the most common medications administered to children. We review the epidemiology and measurement of fever, the meaning of fever and associated clinical signs in children of different ages and under special conditions, including fever in children with cognitive impairment, recurrent fevers, and fever of unknown origin. While the majority of febrile children have mild, self-resolving viral illness, a minority may be at risk of life-threatening infections. Clinical assessment differs markedly from adult patients. Hands-off evaluation is paramount for a correct evaluation of breathing, circulation and level of interaction. Laboratory markers and clinical prediction rules provide limited help in identifying children at risk for serious infections; however, clinical examination, prudent utilization of laboratory tests, and post-discharge guidance ("safety netting") remain the cornerstone of safe management of febrile children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.