ArticleMolecular microbiology2017
A novel MAs(III)-selective ArsR transcriptional repressor.
Article in Molecular microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 56 citations in OpenAlex.
- Quantifying arsenic-binding affinities of ArsR proteins via biomimetic self-assembly.Frontiers in microbiology · 2026Article
- Mechanisms of Arsenic Interaction inInternational journal of molecular sciences · 2025Review
- A new type of ArsR transcriptional repressor controls transcription of the arsenic resistance operon ofmLife · 2025Article
- Biosensor-aided isolation of anaerobic arsenic-methylating bacteria from soil.ISME communications · 2025Article
- Bacterial Metallostasis: Metal Sensing, Metalloproteome Remodeling, and Metal Trafficking.Chemical reviews · 2024Review
- Adaptation to metal(loid)s in strain Mucilaginibacter rubeus P2 involves novel arsenic resistance genes and mechanisms.Journal of hazardous materials · 2024Article
- AsgeneDB: a curated orthology arsenic metabolism gene database and computational tool for metagenome annotation.NAR genomics and bioinformatics · 2022Article
- Meta-omics-aided isolation of an elusive anaerobic arsenic-methylating soil bacterium.The ISME journal · 2022Article
- An InducibleViruses · 2022Article
- Structural and mechanistic basis for redox sensing by the cyanobacterial transcription regulator RexT.Communications biology · 2022Article
- Functional characterization of the methylarsenite-inducible arsRM operon from Noviherbaspirillum denitrificans HC18.Environmental microbiology · 2022Article
- Oxidation of organoarsenicals and antimonite by a novel flavin monooxygenase widely present in soil bacteria.Environmental microbiology · 2022Article
- Organoarsenical tolerance in Sphingobacterium wenxiniae, a bacterium isolated from activated sludge.Environmental microbiology · 2022Article
- ArsV and ArsW provide synergistic resistance to the antibiotic methylarsenite.Environmental microbiology · 2021Article
- Identification of a MarR Subfamily That Regulates Arsenic Resistance Genes.Applied and environmental microbiology · 2021Article
- An ArsR Transcriptional Regulator FacilitatesInternational journal of molecular sciences · 2021Article
- Bacterial approaches to sensing and responding to respiration and respiration metabolites.Molecular microbiology · 2021Review
- High Arsenic Levels Increase Activity Rather than Diversity or Abundance of Arsenic Metabolism Genes in Paddy Soils.Applied and environmental microbiology · 2021Article
- Functional and structural characterization of AntR, an Sb(III) responsive transcriptional repressor.Molecular microbiology · 2021Article
- NemA Catalyzes Trivalent Organoarsenical Oxidation and Is Regulated by the Trivalent Organoarsenical-Selective Transcriptional Repressor NemR.Environmental science & technology · 2021Article
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3 authors at 1 institution in 1 country.
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Abstract
Microbial expression of genes for resistance to heavy metals and metalloids is usually transcriptionally regulated by the toxic ions themselves. Arsenic is a ubiquitous, naturally occurring toxic metalloid widely distributed in soil and groundwater. Microbes biotransform both arsenate (As(V)) and arsenite (As(III)) into more toxic methylated metabolites methylarsenite (MAs(III)) and dimethylarsenite (DMAs(III)). Environmental arsenic is sensed by members of the ArsR/SmtB family. The arsR gene is autoregulated and is typically part of an operon that contains other ars genes involved in arsenic detoxification. To date every identified ArsR is regulated by inorganic As(III). Here we described a novel ArsR from Shewanella putrefaciens selective for MAs(III). SpArsR orthologs control expression of two MAs(III) resistance genes, arsP that encodes the ArsP MAs(III) efflux permease, and arsH encoding the ArsH MAs(III) oxidase. SpArsR has two conserved cysteine residues, Cys101 and Cys102. Mutation of either resulted in loss of MAs(III) binding, indicating that they form an MAs(III) binding site. SpArsR can be converted into an As(III)-responsive repressor by introduction of an additional cysteine that allows for three-coordinate As(III) binding. Our results indicate that SpArsR evolved selectivity for MAs(III) over As(III) in order to control expression of genes for MAs(III) detoxification.
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