Evidence map›Paper›PMID 28861908›Full record

ReviewEuropean journal of immunology2017

Issues in vaccinology: Present challenges and future directions.

Dylan Sheerin, Peter Jm Openshaw, Andrew J Pollard

Abstract readReview
In one paragraph

Review in European journal of immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Pediatrics · 2019
    Trial
  2. Article
  3. Knowledge of the Malaysian National Immunisation Programme and its associated factors among parents in Dungun, Terengganu: A cross-sectional study.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2023
    Article
  4. Review
  5. Moving beyond Titers.Vaccines · 2022
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Adjuvant activity ofHeliyon · 2020
    Article
  11. Article
  12. Review
  13. Metazoan Parasite Vaccines: Present Status and Future Prospects.Frontiers in cellular and infection microbiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dylan SheerinOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.ORCID 0000-0001-9456-5712
Peter Jm OpenshawRespiratory Medicine, National Heart and Lung Institute, Imperial College London, UK.
Andrew J PollardOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.

Funding

Medical Research Council G1000758Medical Research Council MC_G1001212Wellcome Trust
6 · The paper itself

Abstract

Vaccination is a principal and highly cost-effective means of controlling infectious diseases, providing direct protection against pathogens by conferring long-lasting immunological memory and inducing population-level herd immunity. Despite rapid ongoing progress in vaccinology, there remain many obstacles to the development and deployment of novel or improved vaccines; these include the underlying science of how to induce and sustain appropriate protective immune responses as well as bureaucratic, logistic and socio-political hurdles. The failure to distribute and administer existing vaccines to at-risk communities continues to account for a large proportion of infant mortality worldwide: almost 20 million children do not have access to basic vaccines and several million still die each year as a result. While emerging epidemic or pandemic diseases pose a significant threat to global health and prosperity, there are many infectious diseases which provide a continuous or cyclical burden on healthcare systems which also need to be addressed. Gaps in knowledge of the human immune system stand in the way of developing technologies to overcome individual and pathogenic variation. The challenges in tackling infectious disease and directions that the field of preventive medicine may take to improve the current picture of global health are the focus of this review.

Indexed as

ForecastingAdolescentAgedChild, PreschoolGlobal HealthHumansInfantPandemicsVaccinationVaccinesVaccinesDifficult pathogensEmerging infectious diseasesFuture vaccinesImmunisation programmesVaccine-preventable disease

Identifiers

PMID28861908
PMCPMC7163762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.