Evidence map›Paper›PMID 28861778›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2017

Purification and Fibrillation of Full-Length Recombinant PrP.

Natallia Makarava, Regina Savtchenko, Ilia V Baskakov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Natallia MakaravaDepartment of Anatomy and Neurobiology, Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, 111 Penn St., Baltimore, MD, 21201, USA.
Regina SavtchenkoDepartment of Anatomy and Neurobiology, Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, 111 Penn St., Baltimore, MD, 21201, USA.
Ilia V BaskakovDepartment of Anatomy and Neurobiology, Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, 111 Penn St., Baltimore, MD, 21201, USA.

Funding

Self-Propagating Mechanism of Prion DiseasesR01NS045585 · NINDS · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI Ilia V Baskakov · 2003 to 2026
$9.6M
Elucidating molecular structure of mammalian prionsR01NS074998 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI BASKAKOV, ILIA V · 2012 to 2015
$1.4M
Elucidating molecular structure of mammalian prionsR56NS074998 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI BASKAKOV, ILIA V · 2011 to 2011
$405k
NINDS NIH HHS R01 NS045585NINDS NIH HHS R01 NS074998NINDS NIH HHS R56 NS074998
6 · The paper itself

Abstract

Misfolding and aggregation of prion protein are related to several neurodegenerative diseases in humans such as Creutzfeldt-Jakob disease, fatal familial insomnia, and Gerstmann-Straussler-Scheinker disease. A growing number of applications in the prion field including assays for detection of PrP

Indexed as

Protein AggregatesAmyloidAnimalsChromatography, AffinityChromatography, High Pressure LiquidCloning, MolecularCricetulusEscherichia coliGene ExpressionGuanidineHumansInclusion BodiesMicePlasmidsPrion ProteinsProtein RefoldingAmyloidGuanidinePrion ProteinsProtein AggregatesRecombinant ProteinsAmyloid fibrilsConformational transitionHPLCIMACInclusion bodyPrion diseasesProtein purificationRecombinant prion protein

Identifiers

PMID28861778
PMCPMC7052951

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.