Evidence map›Paper›PMID 28861752›Full record

ArticleJournal of experimental orthopaedics2017

Ground reaction forces during walking with different load and slope combinations in rats.

N Bravenboer, B T T M van Rens, H W van Essen, J H van Dieën, P Lips

Open access · goldAbstract read
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In one paragraph

Article in Journal of experimental orthopaedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

N BravenboerAmsterdam Movement Sciences, Department of Clinical Chemistry, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands. n.bravenboer@vumc.nl.ORCID http://orcid.org/0000-0001-5050-2584
B T T M van RensAmsterdam Movement Sciences, Department of Clinical Chemistry, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands.
H W van EssenAmsterdam Movement Sciences, Department of Clinical Chemistry, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands.
J H van DieënAmsterdam Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
P LipsDepartment Internal Medicine, VU University Medical Center, Amsterdam, the Netherlands.
Amsterdam UMC Location Vrije Universiteit Amsterdam · NLVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTreadmill animal models are commonly used to study effects of exercise on bone. Since mechanical loading induces bone strain, resulting in bone formation, exercise that induces higher strains is likely to cause more bone formation. Our aim was to investigate the effect of slope and additional load on limb bone strain.

methodsHorizontal and vertical ground reaction forces on left fore-limb (FL) and hind-limb (HL) of twenty 23-week old female Wistar rats (weight 279 ± 26 g) were measured for six combinations of SLOPE (-10°, 0°, +10°) and LOAD (0 to 23% of body mass). Peak force (Fmax), rate of force rise (RC), stance time (Tstance) and impulse (Fint) on FLs and HLs were analyzed.

resultsFor the FL, peak ground reaction forces and rate of force rise were highest when walking downward -10° with load (Fmax = 2.09±0.05 N, FLRC = 34±2 N/s) For the HL, ground reaction forces and rate of force rise were highest when walking upward +10°, without load (Fmax = 2.20±0.05 N, HLRC = 34±1 N/s). Load increased stance time. Without additional load, estimates for the highest FL loading (slope is -10°) were larger than for the highest HL loading (slope is +10°) relative to level walking.

conclusionsThus, walking downward has a higher impact on FL bones, while walking upward is a more optimal HL exercise. Additional load may have a small effect on FL loading.

Indexed as

Animal modelBoneExerciseLoadingOsteoporosis

Identifiers

PMID28861752
PMCPMC5578952
OpenAlexW2753447837

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.