Evidence map›Paper›PMID 28861741›Full record

ReviewProbiotics and antimicrobial proteins2018

Probiotics and the Gut Immune System: Indirect Regulation.

Giorgio La Fata, Peter Weber, M Hasan Mohajeri

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Probiotics and antimicrobial proteins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 5 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 5 syntheses or guidelines pooled it, 404 citations in OpenAlex.

  1. Pooled it
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  5. Pooled it
  6. Safety and Tolerance ofNutrients · 2025
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  18. Effects ofMicroorganisms · 2026
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130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Giorgio La FataDSM Nutritional Products Ltd., R & D Human Nutrition and Health, P.O. Box 2676, CH-4002, Basel, Switzerland. giorgio.lafata@dsm.com.
Peter WeberDSM Nutritional Products Ltd., R & D Human Nutrition and Health, P.O. Box 2676, CH-4002, Basel, Switzerland.
M Hasan MohajeriDSM Nutritional Products Ltd., R & D Human Nutrition and Health, P.O. Box 2676, CH-4002, Basel, Switzerland.
DSM (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gastrointestinal tract (GIT) represents the largest interface between the human organism and the external environment. In the lumen and upper part of the mucus layer, this organ hosts an enormous number of microorganisms whose composition affects the functions of the epithelial barrier and the gut immune system. Consequentially, the microorganisms in the GIT influence the health status of the organism. Probiotics are living microorganisms which, in specific conditions, confer a health benefit to the host. Among others, probiotics have immunomodulatory properties that usually act directly by (a) increasing the activity of macrophages or natural killer cells, (b) modulating the secretion of immunoglobulins or cytokines, or indirectly by (c) enhancing the gut epithelial barrier, (d) altering the mucus secretion, and (e) competitive exclusion of other (pathogenic) bacteria. This review focuses on specific bacteria strains with indirect immunomodulatory properties. Particularly, we describe here the mechanisms through which specific probiotics enhance the gut epithelial barrier and modulate mucus production. Moreover, we describe the antimicrobial properties of specific bacteria strains. Recent data suggest that multiple pathologies are associated with an unbalanced gut microflora (dysbiosis). Although the cause-effect relationship between pathology and gut microflora is not yet well established, consumption of specific probiotics may represent a powerful tool to re-establish gut homeostasis and promote gut health.

Indexed as

Gastrointestinal MicrobiomeAnimalsBacteriaGastrointestinal TractHumansImmune SystemKiller Cells, NaturalMacrophagesProbioticsGastrointestinal tractHealth statusImmune systemMicrobiotaProbiotic

Identifiers

PMID28861741
PMCPMC5801397
OpenAlexW2751467691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.