Evidence map›Paper›PMID 28861718›Full record

ArticleMolecular neurobiology2018

Repeated Forced Swim Exacerbates Methamphetamine-Induced Neurotoxicity: Neuroprotective Effects of Nanowired Delivery of 5-HT3-Receptor Antagonist Ondansetron.

José Vicente Lafuente, Aruna Sharma, Dafin F Muresanu, Asya Ozkizilcik, Z Ryan Tian, Ranjana Patnaik, Hari S Sharma

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 6 countries.

José Vicente LafuenteLaNCE, Department of Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Biscay, Spain.
Aruna SharmaLaNCE, Department of Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Biscay, Spain.
Dafin F Muresanu"RoNeuro" Institute for Neurological Research and Diagnostic, 37 Mircea Eliade Street, 400364, Cluj-Napoca, Romania.
Asya OzkizilcikDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR, USA.
Z Ryan TianDepartment of Chemistry and Biochemistry, J. William Fulbright College of Arts and Sciences, University of Arkansas, Fayetteville, AR, USA.
Ranjana PatnaikSchool of Biomedical Engineering, Department of Biomaterials, Indian Institute of technology, Banaras Hindu University, Varanasi, India.
Hari S SharmaLaNCE, Department of Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Biscay, Spain. Sharma@surgsci.uu.se.
University of Arkansas at Fayetteville · USBanaras Hindu University · INBioCruces Health research Institute · ESUniversity of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca · ROUniversity of the Basque Country · ESUppsala University Hospital · SE

Funding

Role of Cell Cycle in NeurodegenerationR01AG028679 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI LEE, HYOUNG-GON · 2008 to 2012
$1.6M
NIA NIH HHS R01 AG028679
6 · The paper itself

Abstract

The possibility that stress associated with chronic forced swim (FS) may exacerbate methamphetamine (METH) neurotoxicity was examined in a rat model. Rats were subjected to FS in a pool (30 °C) for 15 min daily for 8 days. Control rats were kept at room temperature. METH was administered (9 mg/kg, s.c.) in both control and FS rats and allowed to survive 4 h after the drug injection. METH in FS rats exacerbated BBB breakdown to Evans blue albumin (EBA) by 150 to 220% and

Indexed as

SwimmingAnimalsBlood-Brain BarrierBrainBrain EdemaDrug Delivery SystemsMaleMethamphetamineNanowiresNeuroprotective AgentsOndansetronRatsRats, Sprague-DawleySerotonin 5-HT3 Receptor AntagonistsMethamphetamineNeuroprotective AgentsOndansetronSerotonin 5-HT3 Receptor Antagonists5-HT3 receptorBlood-brain barrier (BBB)Brain edemaBrain pathologyForced swim (FS)Methamphetamine (METH)OndansetronTiO2 nanodelivery

Identifiers

PMID28861718
OpenAlexW2753897757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.