Evidence map›Paper›PMID 28861570›Full record

ArticleNanoscale2017

NIR-emissive PEG-b-TCL micelles for breast tumor imaging and minimally invasive pharmacokinetic analysis.

Christina L Hofmann, Melanie C O'Sullivan, Alexandre Detappe, Yingjie Yu, Xi Yang, Wei Qi, Chelsea D Landon, Michael J Therien, Mark W Dewhirst, P Peter Ghoroghchian and 1 more

Abstract read
In one paragraph

Article in Nanoscale, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Glutathione-Responsive Nanoparticles of Camptothecin Prodrug for Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  3. Article
  4. Review
  5. Polydopamine-Functionalized CA-(PCL-Frontiers in pharmacology · 2018
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christina L HofmannBiomedical Engineering Department, Duke University, Room 136 Hudson Hall, Durham, NC 27708, USA.
Melanie C O'Sullivan
Alexandre Detappe
Yingjie Yu
Xi Yang
Wei Qi
Chelsea D Landon
Michael J Therien
Mark W Dewhirst
P Peter Ghoroghchian
Gregory M Palmer

Funding

University Training Program in Biomolecular & Tissue EngineeringT32GM008555 · NIGMS · DUKE UNIVERSITY · PI GERSBACH, CHARLES A. · 1994 to 2021
$8.1M
Modulation of In Vivo Tumor Oxygenation via Polymersome-encapsulated MyoglobinR43CA159527 · NCI · VINDICO NANOBIOTECHNOLOGY, INC. · PI GHOROGHCHIAN, PAIMAN PETER · 2011 to 2011
$300k
NCI NIH HHS R43 CA159527NIGMS NIH HHS T32 GM008555
6 · The paper itself

Abstract

Motivated by the goal of developing a fully biodegradable optical contrast agent with translational clinical potential, a nanoparticle delivery vehicle was generated from the self-assembly of poly(ethylene-glycol)-block-poly(trimethylene carbonate-co-caprolactone) (PEG-b-TCL) copolymers. Cryogenic transmission electron microscopy verified that PEG-b-TCL-based micelles were formed at low solution temperatures (∼38 °C). Detailed spectroscopic experiments validated facile loading of large quantities of the high emission dipole strength, tris(porphyrin)-based fluorophore PZn

Indexed as

Contrast MediaMicellesPolyestersPolyethylene GlycolsAnimalsBreast NeoplasmsFemaleHumansHuman Umbilical Vein Endothelial CellsInfrared RaysMiceMice, Inbred BALB CTissue DistributionContrast MediaMicellesPolyestersPolyethylene Glycols

Identifiers

PMID28861570
PMCPMC5661869

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.