Evidence map›Paper›PMID 28861486›Full record

ReviewCannabis and cannabinoid research2016

Cannabinoid Regulation of Acute and Anticipatory Nausea.

Erin M Rock, Martin A Sticht, Cheryl L Limebeer, Linda A Parker

Open access · hybridAbstract readReview
In one paragraph

Review in Cannabis and cannabinoid research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Revisiting the physiology of nausea and vomiting-challenging the paradigm.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Review
  6. Review
  7. Article
  8. Central Aspects of Nausea and Vomiting in GI Disorders.Current treatment options in gastroenterology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Erin M RockDepartment of Psychology and Collaborative Neuroscience Graduate Program, University of Guelph, Guelph, Canada.
Martin A StichtDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
Cheryl L LimebeerDepartment of Psychology and Collaborative Neuroscience Graduate Program, University of Guelph, Guelph, Canada.
Linda A ParkerDepartment of Psychology and Collaborative Neuroscience Graduate Program, University of Guelph, Guelph, Canada.
University of Guelph · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy-induced nausea is one of the most distressing symptoms reported by patients undergoing treatment, and even with the introduction of newer antiemetics such as ondansetron and aprepitant, nausea remains problematic in the clinic. Indeed, when acute nausea is not properly managed, the cues of the clinic can become associated with this distressing symptom resulting in anticipatory nausea for which no effective treatments are available. Clinical trials exploring the potential of exogenous or endogenous cannabinoids to reduce chemotherapy-induced nausea are sparse; therefore, we must rely on the data from pre-clinical rat models of nausea. In this review, we explore the human and pre-clinical animal literature examining the potential for exogenous and endogenous cannabinoid treatments to regulate chemotherapy-induced nausea. The pre-clinical evidence points to a compelling need to evaluate the antinausea potential of cannabidiol, cannabidiolic acid, and treatments that boost the functioning of the endocannabinoid system in human clinical trials.

Indexed as

2-arachidonoylglycerolacute nauseaanandamideanticipatory nauseaCB1 receptorconditioned gapingendocannabinoid

Identifiers

PMID28861486
PMCPMC5576606
OpenAlexW2342372197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.