ArticleScience advances2016
Rapid identification of health care-associated infections with an integrated fluorescence anisotropy system.
Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Nanozyme Aptasensor Array for Predictive Sensing of Virulent and Antibiotic-Resistant Staphylococcus Aureus strains.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Fluorescence Polarization Assay for Infection Diagnostics: A Review.Molecules (Basel, Switzerland) · 2024Review
- Automated and miniaturized screening of antibiotic combinationsActa pharmaceutica Sinica. B · 2024Article
- Characterization of Heat-labile Uracil-DNA Glycosylase fromProtein and peptide letters · 2024Article
- A novel linear displacement isothermal amplification with strand displacement probes (LDIA-SD) in a pocket-size device for point-of-care testing of infectious diseases.Sensors and actuators. B, Chemical · 2023Article
- Bare Eye Detection of Bacterial Enzymes ofBiosensors · 2022Article
- Combinatorial nanodroplet platform for screening antibiotic combinations.Lab on a chip · 2022Article
- Wetting ridge assisted programmed magnetic actuation of droplets on ferrofluid-infused surface.Nature communications · 2021Article
- Development of Integrated Systems for On-Site Infection Detection.Accounts of chemical research · 2021Review
- Multiplexed detection of respiratory pathogens with a portable analyzer in a "raw-sample-in and answer-out" manner.Microsystems & nanoengineering · 2021Article
- Rapid bacterial detection and antibiotic susceptibility testing in whole blood using one-step, high throughput blood digital PCR.Lab on a chip · 2020Article
- Adaptable microfluidic system for single-cell pathogen classification and antimicrobial susceptibility testing.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A simple approach for rapid and cost-effective quantification of extracellular vesicles using a fluorescence polarization technique.Journal of biological engineering · 2019Article
- Handheld Inkjet Printing Paper Chip Based Smart Tetracycline Detector.Micromachines · 2019Article
- Visual and modular detection of pathogen nucleic acids with enzyme-DNA molecular complexes.Nature communications · 2018Article
- Nucleic acid aptamer-based methods for diagnosis of infections.Biosensors & bioelectronics · 2018Review
- Emerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility Testing.SLAS technology · 2017Article
- Nanomagnetic System for Rapid Diagnosis of Acute Infection.ACS nano · 2017Article
- Facile silicification of plastic surface for bioassays.Chemical communications (Cambridge, England) · 2017Article
- Point-of-Care Diagnostics: Recent Developments in a Connected Age.Analytical chemistry · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Health care-associated infections (HAIs) and drug-resistant pathogens have become a major health care issue with millions of reported cases every year. Advanced diagnostics would allow clinicians to more quickly determine the most effective treatment, reduce the nonspecific use of broad-spectrum antimicrobials, and facilitate enrollment in new antibiotic treatments. We present a new integrated system, polarization anisotropy diagnostics (PAD), for rapid detection of HAI pathogens. The PAD uses changes of fluorescence anisotropy when detection probes recognize target bacterial nucleic acids. The technology is inherently robust against environmental noise and economically scalable for parallel measurements. The assay is fast (2 hours) and performed on-site in a single-tube format. When applied to clinical samples obtained from interventional procedures, the PAD determined the overall bacterial burden, differentiated HAI bacterial species, and identified drug resistance and virulence status. The PAD system holds promise as a powerful tool for near-patient, rapid HAI testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.