Evidence map›Paper›PMID 28861464›Full record

Trial reportScience advances2016

Organic electronics for high-resolution electrocorticography of the human brain.

Dion Khodagholy, Jennifer N Gelinas, Zifang Zhao, Malcolm Yeh, Michael Long, Jeremy D Greenlee, Werner Doyle, Orrin Devinsky, György Buzsáki

Abstract readClinical Trial
In one paragraph

Trial report in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Implantable bioelectronic outlet.Science advances · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. PEDOT:PSS-A Key Material for Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. E-Suture: Mixed-Conducting Suture for Medical Devices.Advanced healthcare materials · 2024
    Article
  19. Article
  20. Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dion KhodagholyNYU Neuroscience Institute, School of Medicine, New York University, New York, NY 10016, USA.ORCID 0000-0003-0805-4612
Jennifer N GelinasNYU Neuroscience Institute, School of Medicine, New York University, New York, NY 10016, USA.
Zifang ZhaoNYU Neuroscience Institute, School of Medicine, New York University, New York, NY 10016, USA.
Malcolm YehDepartment of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
Michael LongNYU Neuroscience Institute, School of Medicine, New York University, New York, NY 10016, USA.
Jeremy D GreenleeDepartment of Neurosurgery, Human Brain Research Laboratory, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
Werner DoyleDepartment of Neurosurgery, New York University Langone Medical Center, New York, NY 10016, USA.ORCID 0000-0001-7138-9701
Orrin DevinskyDepartment of Neurology, Comprehensive Epilepsy Center, New York University, New York, NY 10016, USA.
György BuzsákiNYU Neuroscience Institute, School of Medicine, New York University, New York, NY 10016, USA.

Funding

The Hippocampal Interneuron NetworkR01MH054671 · NIMH · RUTGERS THE STATE UNIV OF NJ NEWARK · PI BUZSAKI, GYORGY · 1997 to 2017
$5.2M
Brain rhythms-assisted memory enhancementR01MH107396 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUZSAKI, GYORGY, DEVINSKY, ORRIN · 2015 to 2019
$3.3M
NeuroGrid: a scalable system for large-scale recording of action potentials from the brain surfaceU01NS099705 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUZSAKI, GYORGY, DEVINSKY, ORRIN · 2016 to 2018
$3.0M
Neural mechanisms of vocal communication in the human brainR01DC015260 · NIDCD · UNIVERSITY OF IOWA · PI GREENLEE, JEREMY · 2016 to 2021
$2.6M
Towards a Complete Description of the Circuitry Underlying Memory replay.U01NS090583 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SOLTESZ, IVAN · 2014 to 2016
$2.1M
Modular High-Density Optoelectrodes for Local Circuit Analysis - Administrative SupplementU01NS090526 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUZSAKI, GYORGY, WISE, KENSALL DAVID · 2014 to 2016
$2.0M
NIDCD NIH HHS R01 DC015260NIMH NIH HHS R01 MH054671NIMH NIH HHS R01 MH107396NINDS NIH HHS U01 NS090526NINDS NIH HHS U01 NS090583NINDS NIH HHS U01 NS099705
6 · The paper itself

Abstract

Localizing neuronal patterns that generate pathological brain signals may assist with tissue resection and intervention strategies in patients with neurological diseases. Precise localization requires high spatiotemporal recording from populations of neurons while minimizing invasiveness and adverse events. We describe a large-scale, high-density, organic material-based, conformable neural interface device ("NeuroGrid") capable of simultaneously recording local field potentials (LFPs) and action potentials from the cortical surface. We demonstrate the feasibility and safety of intraoperative recording with NeuroGrids in anesthetized and awake subjects. Highly localized and propagating physiological and pathological LFP patterns were recorded, and correlated neural firing provided evidence about their local generation. Application of NeuroGrids to brain disorders, such as epilepsy, may improve diagnostic precision and therapeutic outcomes while reducing complications associated with invasive electrodes conventionally used to acquire high-resolution and spiking data.

Indexed as

ElectrocorticographyAdultBrainElectronics, MedicalEpilepsyFemaleHumansMaleMiddle Agedconducting polymersepilepsyhuman electrocorticographyNeuroGridOrganic electronics

Identifiers

PMID28861464
PMCPMC5569954

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.