Evidence map›Paper›PMID 28861417›Full record

ArticleAnnals of translational medicine2017

Impact of diverticular inflammation and complication assessment classification on the burden of medical therapies in preventing diverticular disease complications in Italy.

Antonio Tursi, Walter Elisei, Marcello Picchio, Gabriella Nasi, Angela Maria Mastromatteo, Francesco Di Mario, Enrico Di Rosa, Maria Alessandra Brandimarte, Giovanni Brandimarte

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04173182 (Role of Peridiverticular and Colonic Mucosa Inflammation Based on Confocal Laser Endomicroscopy in the Prediction of Complicated Diverticular Disease), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04173182 completednot on this mapstarted 2019, after this paper: background citation

Role of Peridiverticular and Colonic Mucosa Inflammation Based on Confocal Laser Endomicroscopy in the Prediction of Complicated Diverticular Disease

TypeobservationalSponsorInstituto Ecuatoriano de Enfermedades DigestivasRan2019 to 2021Enrolled63ConditionsDiverticular Disease, Diverticulitis, DiverticulaArmsProbe-based confocal laser endomicroscopy evaluation
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Colonic diverticular disease.Nature reviews. Disease primers · 2020
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Antonio TursiGastroenterology Service, ASL BAT, Andria, Italy.
Walter EliseiDivision of Gastroenterology, ASL RM6, Albano Laziale, Rome, Italy.
Marcello PicchioDivision of Surgery, "P. Colombo" Hospital, ASL RM6, Velletri, Rome, Italy.
Gabriella NasiClinical Management Staff, "Cristo Re" Hospital, Rome, Italy.
Angela Maria MastromatteoClinical Management Staff, "Cristo Re" Hospital, Rome, Italy.
Francesco Di MarioDepartment of Clinical & Experimental Medicine, Gastroenterology Unit, University of Parma, Parma, Italy.
Enrico Di RosaDepartment of Hygiene and Public Health, ASL RM1, Rome, Italy.
Maria Alessandra BrandimarteDepartment of Hygiene and Public Health, ASL RM1, Rome, Italy.
Giovanni BrandimarteDivision of Internal Medicine and Gastroenterology, "Cristo Re" Hospital, Rome, Italy.
Azienda Sanitaria Locale Roma 3 · ITOspedale Cristo Re · ITOspedale L. Bonomo · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral treatments are currently advised to manage diverticular disease (DD) patients, but their impact on the burden of the disease is unknown. Our aim was to assess the economic analysis of using the recent Diverticular Inflammation and Complication Assessment (DICA) endoscopic classification on the burden of medical therapies prescribed in preventing DD complications occurrence in Italy.

methodsWe assessed retrospectively the cost/year of treatments in estimated DICA 1, DICA 2 and DICA 3 population. Analysis of diverticulosis prevalence was estimated according to data population provided by Italian Institute of Statistics (ISTAT). Cost of treatments calculated according to data on drugs' consumption collected during the DICA study.

resultsWe estimated that >8 million of Italian people >60 years may have diverticulosis, and that about 75% of diverticular population are on DICA 1, about 30% on DICA 2, and about 13% on DICA 3. We estimated that >387 million of euros could be spent in DICA 1 population, >203 million of euros in DICA 2 population, and >88 million of euros in DICA 3 population. Since medical treatments did not show any significant advantage when treating DICA 1 and DICA 3 people in terms of prevention of acute diverticulitis occurrence/recurrence and surgery occurrence, we can estimated that >475 million of euros could be spent in Italy without any significant benefit in preventing DD complications occurrence.

conclusionsDICA endoscopic classification may have a significant impact on the burden of DD in Italy, because it helps to select DD people who effectively need treatments in terms of prevention of acute diverticulitis occurrence/recurrence and surgery occurrence.

Indexed as

Acute diverticulitisburdenDiverticular Inflammation and Complication Assessment classification (DICA classification)preventionsurgery

Identifiers

PMID28861417
PMCPMC5566732
OpenAlexW2738779270

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.