ReviewFrontiers in pediatrics2017
Alterations in Cerebral Blood Flow after Resuscitation from Cardiac Arrest.
Review in Frontiers in pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 75 citations in OpenAlex.
- Nitric oxide synthase inhibition in healthy adults reduces regional and total cerebral macrovascular blood flow and microvascular perfusion.The Journal of physiology · 2021Trial
- Bedside microdialysis for detection of early brain injury after out-of-hospital cardiac arrest.Scientific reports · 2021Trial
- Neuroprognostication After Extracorporeal Cardiopulmonary Resuscitation: ECMO-Specific Challenges and a Multimodal Time-Sensitive Framework.Journal of cardiovascular development and disease · 2026Review
- Postresuscitation Cerebral Vasospasm and Capillary Failure After Experimental Asphyxial Cardiac Arrest.Journal of the American Heart Association · 2026Article
- Temporal dissociation between cerebral blood flow and brain tissue oxygenation during CPR: observations from a porcine model.Korean journal of anesthesiology · 2026Article
- When the gatekeeper falls: developmental vulnerability of the thalamic reticular nucleus in neonatal and pediatric hypoxic-ischemic brain injury.Frontiers in systems neuroscience · 2026Review
- Impaired Cerebral Autoregulation in Children.Pediatric neurology · 2025Review
- Comprehensive pre- and in-hospital near-infrared-spectroscopy (NIRS) monitoring after return of spontaneous circulation predicts neurological outcome following out-of-hospital cardiac arrest: a prospective observational study and literature review.Frontiers in medicine · 2025Article
- Cerebral Autoregulation: A Target for Improving Neurological Outcomes in Extracorporeal Life Support.Neurocritical care · 2024Review
- Impact of arginine-vasopressin on regional perfusions in a porcine model of post-resuscitation syndrome.Resuscitation plus · 2024Article
- Association between ASL MRI-derived cerebral blood flow and outcomes after pediatric cardiac arrest.Resuscitation · 2024Observational
- Neuromonitoring after Pediatric Cardiac Arrest: Cerebral Physiology and Injury Stratification.Neurocritical care · 2024Review
- Endogenous orexin and hyperacute autonomic responses after resuscitation in a preclinical model of cardiac arrest.Frontiers in neuroscience · 2024Article
- Neuroprotective-Neurorestorative Effects Induced by Progesterone on Global Cerebral Ischemia: A Narrative Review.Pharmaceutics · 2023Review
- Quantification of Cerebral Vascular Autoregulation Immediately Following Resuscitation from Cardiac Arrest.Annals of biomedical engineering · 2023Article
- General Critical Care, Temperature Control, and End-of-Life Decision Making in Patients Resuscitated from Cardiac Arrest.Journal of clinical medicine · 2023Review
- Lapses of the Heart: Frequency and Subjective Salience of Impressions Reported by Patients after Cardiac Arrest.Journal of clinical medicine · 2023Article
- Extracorporeal cardiopulmonary resuscitation (eCPR) and cerebral perfusion: A narrative review.Resuscitation · 2023Review
- Mathematical Model of Blood Circulation with Compression of the Prototype's Mechanical CPR Waveform.Bioengineering (Basel, Switzerland) · 2022Article
- Effects of adrenaline and vasopressin on cerebral microcirculation at baseline and during global brain ischemia and reperfusion in rabbits.BMC anesthesiology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Greater than 50% of patients successfully resuscitated from cardiac arrest have evidence of neurological disability. Numerous studies in children and adults, as well as in animal models have demonstrated that cerebral blood flow (CBF) is impaired after cardiac arrest. Stages of cerebral perfusion post-resuscitation include early hyperemia, followed by hypoperfusion, and finally either resolution of normal blood flow or protracted hyperemia. At the level of the microcirculation the blood flow is heterogeneous, with areas of no flow, low flow, and increased flow. CBF directed therapies in animal models of cardiac arrest improved neurological outcome, and therefore, the alterations in CBF after cardiac arrest likely contribute to the development of hypoxic ischemic encephalopathy. Current intensive care after cardiac arrest is centered upon maintaining systemic oxygenation, normal blood pressure values for age, maintaining general homeostasis, and avoiding hyperthermia. Assessment of CBF and oxygenation is not routinely performed after cardiac arrest. Currently available and underutilized techniques to assess cerebral perfusion include transcranial doppler, near-infrared spectroscopy, and arterial spin labeling magnetic resonance imaging. Limited clinical studies established the role of CBF and oxygenation monitoring in prognostication after cardiac arrest and few studies suggest that guiding critical care post-resuscitation to mean arterial pressures above the minimal autoregulatory range might improve outcome. Important knowledge gaps thus remain in cerebral monitoring and CBF and oxygen goal-directed therapies post-resuscitation from cardiac arrest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.