Evidence map›Paper›PMID 28861398›Full record

ArticleFrontiers in cellular and infection microbiology2017

Extensive Metabolic Remodeling Differentiates Non-pathogenic and Pathogenic Growth Forms of the Dimorphic Pathogen

Shivani Pasricha, James I MacRae, Hwa H Chua, Jenny Chambers, Kylie J Boyce, Malcolm J McConville, Alex Andrianopoulos

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Glutathione Peroxidase fromInternational journal of molecular sciences · 2026
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  7. HIV-negative case ofThe Journal of international medical research · 2021
    Article
  8. Comparative Proteomic Analysis ofFrontiers in microbiology · 2021
    Article
  9. Article
  10. Article
  11. Metabolic Peculiarities ofFrontiers in microbiology · 2019
    Article
  12. mSphere
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shivani PasrichaGenetics, Genomics and Systems Biology, School of BioSciences, University of MelbourneParkville, VIC, Australia.
James I MacRaeDepartment of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of MelbourneParkville, VIC, Australia.
Hwa H ChuaDepartment of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of MelbourneParkville, VIC, Australia.
Jenny ChambersDepartment of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of MelbourneParkville, VIC, Australia.
Kylie J BoyceGenetics, Genomics and Systems Biology, School of BioSciences, University of MelbourneParkville, VIC, Australia.
Malcolm J McConvilleDepartment of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of MelbourneParkville, VIC, Australia.
Alex AndrianopoulosGenetics, Genomics and Systems Biology, School of BioSciences, University of MelbourneParkville, VIC, Australia.
University of Melbourne · AU

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Fungal infections are an increasing public health problem, particularly in immunocompromised individuals. While these pathogenic fungi show polyphyletic origins with closely related non-pathogenic species, many undergo morphological transitions to produce pathogenic cell types that are associated with increased virulence. However, the characteristics of these pathogenic cells that contribute to virulence are poorly defined.

Indexed as

MetabolomicsAmino AcidsAnimalsCarbohydrate MetabolismCarbonCitric Acid CycleGene Expression Regulation, FungalHost-Pathogen InteractionsHumansHyphaeInositolMacrophagesMitochondriaMycosesSpores, FungalStaining and LabelingAmino AcidsCarbonInositolcentral carbon metabolismdimorphic switchingmetabolomicsnutrient acquisitionpathogenic fungiTalaromyces marneffei

Identifiers

PMID28861398
PMCPMC5563070
OpenAlexW2746537738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.