A human recombinant IL-7/HGFβ hybrid cytokine enhances antitumor immunity in mice.

Feng Han, Rong Hu, Min Su, Yanni Yu, Hua Yang, Laijun Lai

Abstract read

In one paragraph

Article in American journal of cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Tumor cells ectopically expressing the membrane-bound form of IL-7 develop an antitumor immune response efficiently in a colon carcinoma model.Molecules and cells · 2025
Article
Serum Cytokine Profiles of Melanoma Patients and Their Association with Tumor Progression and Metastasis.Journal of oncology · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Feng HanThe Affiliated Hospital of Guizhou Medical University, University of ConnecticutStorrs, CT, USA.

Rong HuDepartment of Allied Health Sciences, University of ConnecticutStorrs, CT, USA.

Min SuDepartment of Allied Health Sciences, University of ConnecticutStorrs, CT, USA.

Yanni YuThe Affiliated Hospital of Guizhou Medical University, University of ConnecticutStorrs, CT, USA.

Hua YangThe Affiliated Hospital of Guizhou Medical University, University of ConnecticutStorrs, CT, USA.

Laijun LaiDepartment of Allied Health Sciences, University of ConnecticutStorrs, CT, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We purified a hybrid cytokine that contains interleukin-7 (IL-7) and the beta-chain of hepatocyte growth factor (HGFβ) from a unique long-term murine bone marrow culture system. We have cloned and expressed the human form of IL-7/HGFβ in which the IL-7 and HGFβ genes are connected by a flexible linker to produce a single-chain recombinant human IL-7/HGFβ protein (hrIL-7/HGFβ). To determine whether hrIL-7/HGFβ has antitumor activity, we injected this hybrid cytokine into melanoma and colon cancer animal models, and then assessed the local tumor growth and tumor metastasis. We show here that

Indexed as

cytokinesdendritic cellsmetastasismiceT cellsTumor immunotherapy

Identifiers

PMID28861327

PMCPMC5574943

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.